R
Rivka Jungreis
Researcher at New York University
Publications - 4
Citations - 2747
Rivka Jungreis is an academic researcher from New York University. The author has contributed to research in topics: Unfolded protein response & Endoplasmic reticulum. The author has an hindex of 4, co-authored 4 publications receiving 2528 citations.
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Journal ArticleDOI
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
Stefan J. Marciniak,Chi Yun,Seiichi Oyadomari,Isabel Novoa,Yuhong Zhang,Rivka Jungreis,Kazuhiro Nagata,Heather P. Harding,David Ron +8 more
TL;DR: This work finds that CHOP directly activates GADD34, which promotes ER client protein biosynthesis by dephosphorylating phospho-Ser 51 of the alpha-subunit of translation initiation factor 2 (eIF2alpha) in stressed cells, and protects cells from ER stress by decreasing client protein load and changing redox conditions within the organelle.
Journal ArticleDOI
Stress induced gene expression requires programmed recovery from translational repression
TL;DR: Observations indicate that GADD34 controls a programmed shift from translational repression to stress‐induced gene expression, and reconciles the apparent contradiction between the translational and transcriptional arms of cellular stress responses.
Journal ArticleDOI
Increased sensitivity to dextran sodium sulfate colitis in IRE1β-deficient mice
Anne Bertolotti,Xiaozhong Wang,Isabel Novoa,Rivka Jungreis,Karni Schlessinger,Judy H. Cho,A. Brian West,David Ron +7 more
TL;DR: Findings are consistent with a model whereby perturbations in ER function, which are normally mitigated by the activity of IRE1beta, participate in the development of colitis.
Journal ArticleDOI
IRE1β Inhibits Chylomicron Production by Selectively Degrading MTP mRNA
Jahangir Iqbal,Kezhi Dai,Tracie A. Seimon,Rivka Jungreis,Miho Oyadomari,George Kuriakose,David Ron,Ira Tabas,M. Mahmood Hussain +8 more
TL;DR: Cell culture studies show that inositol-requiring enzyme 1beta plays a role in regulating MTP and in chylomicron production, and knockdown of IRE1beta enhanced MTP expression.