R
Rob van't Hof
Researcher at University of Liverpool
Publications - 75
Citations - 4157
Rob van't Hof is an academic researcher from University of Liverpool. The author has contributed to research in topics: Osteoclast & Bone resorption. The author has an hindex of 26, co-authored 75 publications receiving 3773 citations. Previous affiliations of Rob van't Hof include Western General Hospital & University of Aberdeen.
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Journal ArticleDOI
Nitric oxide and bone.
Rob van't Hof,Stuart H. Ralston +1 more
TL;DR: Preliminary evidence suggests that the l‐arginine/NO pathway represents a novel target for therapeutic intervention in the prevention and treatment of bone diseases.
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Protein geranylgeranylation is required for osteoclast formation, function, and survival: inhibition by bisphosphonates and GGTI-298.
Fraser P. Coxon,Miep H. Helfrich,Rob van't Hof,Said M. Sebti,Stuart H. Ralston,Andrew D. Hamilton,Michael J. Rogers +6 more
TL;DR: The results therefore show the molecular mechanism of action of nitrogen‐containing bisphosphonate drugs in osteoclasts and highlight the fundamental importance of geranylgeranylated proteins in osteoclast formation and function.
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Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors
Aymen I. Idris,Aymen I. Idris,Rob van't Hof,Rob van't Hof,Iain R. Greig,Susan A Ridge,David Baker,Ruth A. Ross,Stuart H. Ralston,Stuart H. Ralston +9 more
TL;DR: The studies show that the CB1 receptor has a role in the regulation of bone mass and ovariectomy-induced bone loss and that CB1- and CB2-selective cannabinoid receptor antagonists are a new class of osteoclast inhibitors that may be of value in the treatment of osteoporosis and other bone diseases.
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Aminobisphosphonates Cause Osteoblast Apoptosis and Inhibit Bone Nodule Formation In Vitro
TL;DR: It is concluded that aminobisphosphonates cause osteoblast apoptosis in vitro at micromolar concentrations and inhibit osteoblasts differentiation at nanomolar concentrations by mechanisms that are independent of effects on protein prenylation and may be due in part to inhibition of mineralization.
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Genetic and environmental determinants of peak bone mass in young men and women
Fiona E. McGuigan,Liam J. Murray,Alison M. Gallagher,George Davey-Smith,Charlotte E. Neville,Rob van't Hof,Colin Boreham,Stuart H. Ralston +7 more
TL;DR: It is concluded that peak bone mass is regulated by an overlapping but distinct set of environmental and genetic influences that differ in men and women.