R
Robert A. Harris
Researcher at Indiana University – Purdue University Indianapolis
Publications - 15
Citations - 480
Robert A. Harris is an academic researcher from Indiana University – Purdue University Indianapolis. The author has contributed to research in topics: Glycolysis & PDK4. The author has an hindex of 12, co-authored 15 publications receiving 427 citations. Previous affiliations of Robert A. Harris include Veterans Health Administration & Indiana University.
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Journal ArticleDOI
PPARα ligand protects during cisplatin-induced acute renal failure by preventing inhibition of renal FAO and PDC activity
Shenyang Li,Pengfei Wu,Padma Yarlagadda,Nicole M. Vadjunec,Alan D. Proia,Robert A. Harris,Didier Portilla +6 more
TL;DR: It is concluded that PPAR alpha agonists have therapeutic potential for cisplatin-induced acute renal failure by ameliorating cisplarin-induced inhibition of two distinct metabolic processes, MCAD-mediated fatty acid oxidation and PDC activity.
Journal ArticleDOI
Overexpression of pyruvate dehydrogenase kinase 4 in heart perturbs metabolism and exacerbates calcineurin-induced cardiomyopathy
Guixiang Zhao,Nam Ho Jeoung,Shawn C. Burgess,Kimberly A. Rosaaen-Stowe,Takeshi Inagaki,Shuaib Latif,John M. Shelton,John McAnally,Rhonda Bassel-Duby,Robert A. Harris,James A. Richardson,Steven A. Kliewer +11 more
TL;DR: It is demonstrated that cardiac-specific overexpression of PDK4 is sufficient to cause a loss of metabolic flexibility that exacerbates cardiomyopathy caused by the calcineurin stress-activated pathway.
Journal ArticleDOI
Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells
Xiwen Xiong,Gaihong Wang,Rongya Tao,Pengfei Wu,Tatsuyoshi Kono,Kevin Li,Wen-Xing Ding,Xin Tong,Sarah A. Tersey,Robert A. Harris,Robert A. Harris,Raghavendra G. Mirmira,Carmella Evans-Molina,Carmella Evans-Molina,X. Charlie Dong +14 more
TL;DR: These data suggest that Sirt6 is important for GSIS from pancreatic beta cells and activation of SIRT6 may be useful to improve insulin secretion in diabetes.
Journal ArticleDOI
Oxidative metabolism in YAC128 mouse model of Huntington's disease
James Hamilton,Jessica J. Pellman,Tatiana Brustovetsky,Robert A. Harris,Nickolay Brustovetsky +4 more
TL;DR: Overall, the data argue against respiratory deficiency in YAC128 mice and, consequently, suggest that mitochondrial respiratory dysfunction is not essential for HD pathogenesis.
Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells
Xiwen Xiong,Gaihong Wang,Rongya Tao,Pengfei Wu,Tatsuyoshi Kono,Kevin Li,Wen-Xing Ding,Xin Tong,Sarah A. Tersey,Robert A. Harris,Robert A. Harris,Raghavendra G. Mirmira,Carmella Evans-Molina,Carmella Evans-Molina,X. Charlie Dong +14 more
TL;DR: In this article, the role of SIRT6 in pancreatic beta cells was investigated, and the authors found that SIRT 6 has an important role in aging, DNA repair and metabolism.