N
Nickolay Brustovetsky
Researcher at Indiana University
Publications - 78
Citations - 4236
Nickolay Brustovetsky is an academic researcher from Indiana University. The author has contributed to research in topics: Mitochondrion & Mitochondrial permeability transition pore. The author has an hindex of 34, co-authored 75 publications receiving 3785 citations. Previous affiliations of Nickolay Brustovetsky include Ludwig Maximilian University of Munich & University of Minnesota.
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Journal ArticleDOI
Mitochondrial ADP/ATP carrier can be reversibly converted into a large channel by Ca2+
TL;DR: The AAC, when converted into a large unselective channel, is a key component in the MTP and thus is involved in the ischemia-reperfusion damage and cytosolic Ca2+ oscillations.
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Calcium-induced cytochrome c release from CNS mitochondria is associated with the permeability transition and rupture of the outer membrane.
TL;DR: The release of Cyt c from CNS mitochondria induced by Ca2+in vitro as well as in situ involved the mPT and appeared to require the rupture of the outer membrane.
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Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock.
Charlie Mantel,Heather O'Leary,Brahmananda R. Chitteti,Xinxin Huang,Scott Cooper,Giao Hangoc,Nickolay Brustovetsky,Edward F. Srour,Man Ryul Lee,Man Ryul Lee,Steve Messina-Graham,David M. Haas,Nadia Falah,Reuben Kapur,Louis M. Pelus,Nabeel Bardeesy,Julien Fitamant,Mircea Ivan,Kye Seong Kim,Hal E. Broxmeyer +19 more
TL;DR: In this article, the extraphysiologic oxygen shock/stress (EPHOSS) phenomenon was found to decrease the recovery of long-term repopulating HSCs and increase progenitor cells.
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Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex
Joel M. Brittain,Djane B. Duarte,Sarah M. Wilson,Weiguo Zhu,Carrie J. Ballard,Philip L. Johnson,Nai-Kui Liu,Wenhui Xiong,Matthew S. Ripsch,Yuying Wang,Jill C. Fehrenbacher,Stephanie D. Fitz,May Khanna,Chul Park,Brian S. Schmutzler,Bo M. Cheon,Michael R. Due,Tatiana Brustovetsky,Nicole M. Ashpole,Andy Hudmon,Samy O. Meroueh,Cynthia M. Hingtgen,Nickolay Brustovetsky,Ru-Rong Ji,Joyce H. Hurley,Xiaoming Jin,Anantha Shekhar,Xiao Ming Xu,Gerry Stephen Oxford,Michael R. Vasko,Fletcher A. White,Rajesh Khanna +31 more
TL;DR: By preventing CRMP-2–mediated enhancement of CaV2.2 function, TAT-CBD3 alleviated inflammatory and neuropathic hypersensitivity, an approach that may prove useful in managing chronic pain.
Journal ArticleDOI
Increased susceptibility of striatal mitochondria to calcium-induced permeability transition.
Nickolay Brustovetsky,Tatiana Brustovetsky,Kevin J. Purl,Michela Capano,Martin Crompton,Janet M. Dubinsky +5 more
TL;DR: Striatal mitochondria may be selectively vulnerable to the permeability transition, and subsequent mitochondrial dysfunction could contribute to the initial toxicity of striatal neurons in Huntington's disease.