Robert A. Holmgren

TL;DR: Expression of these three Gli genes in various ectoderm- and mesoderm -derived tissues suggests that they play multiple roles during postimplantation development, and a naturally occurring Gli-3 mutation, the mouse extra-toes mutant; shows defects in both mesodermott- and ectoderman-derived tissues.

TL;DR: Restriction enzyme cleavage of the fragments generated indicates that the preferential DNAase I cleavage sites in chromatin are position-specific, and this nuclease also cleaves at position- specific sites.

TL;DR: The distribution of the ciprotein is altered in fused, hedgehog and wingless mutants suggesting cell-cell signaling may regulate ci protein levels.

TL;DR: Sequence analysis indicates that the protein encoded by the ciD transcript contains a domain of five tandem amino acid repeats that have sequence similarity to the zinc-finger repeats of the Xenopus transcription factor TFIIIA and that share the highest degree of identity with the human zinc- finger protein GLI, which has been found to be amplified in several human glioblastomas.

TL;DR: In addition to their functions in epidermal pattern formation, at least four of the segment polarity genes appear to have specific roles in the control of cell fates during neurogenesis, including gooseberry, patched, Cell, and wingless.