Robert C. Mucic

TL;DR: A method for assembling colloidal gold nanoparticles rationally and reversibly into macroscopic aggregates by using the specificity of DNA interactions to direct the interactions between particles of different size and composition is described.

TL;DR: A highly selective, colorimetric polynucleotide detection method based on mercaptoalkyloligonucleotide-modified gold nanoparticle probes is reported, which can detect about 10 femtomoles of an oligonucleotide.

TL;DR: In this new nanoparticle-based detection system, Au particles are used to complex a 24-base polynucleotide target and exhibit characteristic, exceptionally sharp “melting transitions” which allows one to distinguish target sequences that contain one base end mismatches, deletions, or an insertion from the fully complementary target.

TL;DR: Oligonucleotide surface coverages of hexanethiol 12-mer oligonucleotides on gold nanoparticles were significantly higher than on planar gold thin films, and olig onucleotide spacer sequences improve the hybridization efficiency of oligon nucleotide-modified nanoparticles from approximately 4 to 44%.

TL;DR: In this paper, a method for detecting a nucleic acid is described. The method comprises contacting the nucleic acids with one or more types of particles having oligonucleotides attached thereto, and a detectable change (preferably a color change) is brought about as a result of the hybridization of the oligon nucleotides on the nanoparticles to the nucleus.