R
Robert D. Larsen
Researcher at Roswell Park Cancer Institute
Publications - 4
Citations - 127
Robert D. Larsen is an academic researcher from Roswell Park Cancer Institute. The author has contributed to research in topics: Beta (finance) & Alpha (ethology). The author has an hindex of 4, co-authored 4 publications receiving 127 citations.
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Specificity analysis of three clonal and five non-clonal alpha 1,3-L-fucosyltransferases with sulfated, sialylated, or fucosylated synthetic carbohydrates as acceptors in relation to the assembly of 3'-sialyl-6'-sulfo Lewis x (the L-selectin ligand) and related complex structures.
E. V. Chandrasekaran,Rakesh K. Jain,Robert D. Larsen,Ken Wlasichuk,Richard A. DiCioccio,Khushi L. Matta +5 more
TL;DR: Unique specificities of the cloned alpha 1,3-L-fucosyltransferases (FTs), FT III, FT IV, and FT V (myeloid type), and the alpha 1-3-FTs of Colo 205 (colon carcinoma), HL 60, HL60, B142, EKVX, and calf mesenteric lymph nodes (CMLN) were discerned with sulfated, sialylated, and/or f
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Selectin ligands and tumor-associated carbohydrate structures: specificities of alpha 2,3-sialyltransferases in the assembly of 3'-sialyl-6-sialyl/sulfo Lewis a and x, 3'-sialyl-6'-sulfo Lewis x, and 3'-sialyl-6-sialyl/sulfo blood group T-hapten.
TL;DR: The sequence in the assembly of the functional unit of selectin ligands containing sulfate, sialic acid, and fucose and also tumor-associated O-glycan structures was studied by examining the specificities of alpha 2,3-sialyltransferases (ST).
Journal ArticleDOI
Expression of blood group Lewis b determinant from Lewis a: association of this novel alpha (1,2)-L-fucosylating activity with the Lewis type alpha (1,3/4)-L-fucosyltransferase.
E. V. Chandrasekaran,Rakesh K. Jain,John Rhodes,Cheryl A. Srnka,Robert D. Larsen,Khushi L. Matta +5 more
TL;DR: The present study demonstrates the association of this new type of alpha (1,2)- L-fucosyltransferase (FT) activity with the Lewis-type alpha ( 1,3/4)-L-FT, which was highly effective in fucOSylating complex glycopeptides.
Journal ArticleDOI
Characterization of the specificities of human blood group H gene-specified alpha 1,2-L-fucosyltransferase toward sulfated/sialylated/fucosylated acceptors: evidence for an inverse relationship between alpha 1,2-L-fucosylation of Gal and alpha 1,6-L-fucosylation of asparagine-linked GlcNAc.
TL;DR: The assembly of complex structures bearing the H determinant was examined by characterizing the specificities of a cloned blood group H gene-specified alpha 1,2-L-fucosyltransferase toward a variety of sulfated, sialylated, or fucosyated Gal beta 1,3/4GlcNAc beta- or Gal beta1,3GalNAc alpha-based acceptor structures.