K
Khushi L. Matta
Researcher at Roswell Park Cancer Institute
Publications - 314
Citations - 6292
Khushi L. Matta is an academic researcher from Roswell Park Cancer Institute. The author has contributed to research in topics: Trisaccharide & Disaccharide. The author has an hindex of 40, co-authored 312 publications receiving 6124 citations. Previous affiliations of Khushi L. Matta include State University of New York System & Gunma University.
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Journal ArticleDOI
Mammalian Notch1 Is Modified with Two Unusual Forms ofO-Linked Glycosylation Found on Epidermal Growth Factor-like Modules
Daniel J. Moloney,Louisa H. Shair,Frederick M. Lu,Jie Xia,Robert D. Locke,Khushi L. Matta,Robert S. Haltiwanger +6 more
TL;DR: It is shown that Notch1 endogenously expressed in Chinese hamster ovary cells is modified with O-linked fucose andO-linked glucose saccharides, two unusual forms of O- linked glycosylation found on epidermal growth factor-like (EGF) modules.
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Alterations of O-glycan biosynthesis in human colon cancer tissues
Ji Mao Yang,James C. Byrd,Bader Siddiki,Yong-Suk Chung,Masahiro Okuno,Michio Sowa,Young S. Kim,Khushi L. Matta,Inka Brockhausen +8 more
TL;DR: The data suggest that the biosynthesis of antigens and mucin-bound O-glycan structures in colon cancer is subject to complex control mechanisms.
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Use of 1,2-dichloro 4,5-dicyanoquinone (DDQ) for cleavage of the 2-naphthylmethyl (NAP) group
TL;DR: The 2-naphthylmethyl (NAP) group is a versatile group for protection of hydroxyl functions as discussed by the authors, it is stable to 4% TFA in CHCl 3, hot 80% HOAc-H 2 O, SnCl 2 -AgOTf and HCl-EtOH, but it can readily be removed with DDQ in CH 2 Cl 2
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Isolation and Characterization of Amaranthin, a Lectin Present in the Seeds of Amaranthus caudatus, That Recognizes the T- (or Cryptic T)-Antigen
TL;DR: Hapten inhibition of precipitate formation between amaranthin and asialo-ovine submaxillary indicated that the T-disaccharide and its alpha-linked glycosides were the best inhibitors and the C'-4 axial hydroxyl group of the galactosyl moiety are the most important loci for lectin interaction.
Journal ArticleDOI
O‐glycan biosynthesis in human colorectal adenoma cells during progression to cancer
Fabienne Vavasseur,Kiran Dole,Jimmy Yang,Khushi L. Matta,Neil Myerscough,Anthony P. Corfield,Christos Paraskeva,Inka Brockhausen +7 more
TL;DR: The first report of glycosyltransferase changes in human premalignant cells developing to tumourigenic cells is reported, demonstrating that these cell lines are an excellent model to study the changes and regulation of mucin oligosaccharide biosynthesis during progression to cancer.