Robert Driscoll

TL;DR: The results reveal a clear association between elevated levels of tenascin‐W and the presence of cancer and warrant further studies to evaluate the potential value of serum and tissue tenascIn‐W levels as diagnostic, prognostic or monitoring biomarker in colorectal, breast and possibly other solid cancers.

TL;DR: Only VEGF‐A and MMP‐9 consistently correlated to each other, elevated CRP levels were associated with tumor burden, whereas sVEGF‐R1 increased after tumor removal in colorectal cancer.

TL;DR: It is necessary to identify and validate molecular, cellular and functional surrogate markers of angiogenesis to monitor activity and efficacy of anti-angiogenic drugs in patients and to identify new molecular targets and drugs, and to improve planning, monitoring and interpretation of future studies.

TL;DR: HD vectors are as efficient as ΔE1 vectors at transducing the myocardium and vascular endothelium, while causing less myocardial inflammation, and may be superior to earlier-generation adenovirus vectors for cardiovascular gene therapy applications.

TL;DR: It is shown that multiply attenuated, self-inactivating, lentiviral vectors transduce both proliferating and growth-arrested human umbilical vein ECs, human coronary artery ECs), and human coronary arteries smooth muscle cells, with high efficacy.