M
Martin Degen
Researcher at University of Bern
Publications - 29
Citations - 870
Martin Degen is an academic researcher from University of Bern. The author has contributed to research in topics: Tenascin & Tenascin C. The author has an hindex of 14, co-authored 25 publications receiving 756 citations. Previous affiliations of Martin Degen include Friedrich Miescher Institute for Biomedical Research & Brigham and Women's Hospital.
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Journal ArticleDOI
Role of cytoplasmic C-terminal amino acids of membrane proteins in ER export.
Oliver Nufer,Svend Guldbrandsen,Martin Degen,Felix Kappeler,Jean-Pierre Paccaud,Katsuko Tani,Hans-Peter Hauri +6 more
TL;DR: It is suggested that cytoplasmic C-terminal amino-acid motifs, either alone or in conjunction with other transport determinants, accelerate ER export of numerous type I and probably polytopic membrane proteins by mediating interaction with COPII coat components.
Journal ArticleDOI
Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin-dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro
Arnaud Scherberich,Richard P. Tucker,Martin Degen,Marianne Brown-Luedi,Anne-Catherine Andres,Ruth Chiquet-Ehrismann +5 more
TL;DR: The results show that tenascin-W may be a useful diagnostic marker for breast malignancies, and that the induction of tenascIn-W in the tumor stroma may contribute to the invasive behavior of tumor cells.
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Tenascin-W is a novel marker for activated tumor stroma in low-grade human breast cancer and influences cell behavior
Martin Degen,Florence Brellier,Renate Kain,Christian Ruiz,Luigi Terracciano,Gertraud Orend,Ruth Chiquet-Ehrismann +6 more
TL;DR: Interestingly, tenascin-W expression in the activated tumor stroma facilitates tumorigenesis by supporting the migratory behavior of breast cancer cells, and addition of tenascInW to the culture medium increased migration of breast cancers cells toward a fibronectin substratum in vitro.
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Clinical Classification of Cancer Cachexia: Phenotypic Correlates in Human Skeletal Muscle
Neil Johns,Shinji Hatakeyama,Nathan A. Stephens,Martin Degen,Simone Degen,Wilfried Frieauff,Christian Lambert,James A. Ross,Ronenn Roubenoff,David J. Glass,Carsten Jacobi,Kenneth C. H. Fearon +11 more
TL;DR: Muscle fibre size, biochemical composition and pathway phenotype can vary according to whether the diagnostic criteria for cachexia are based on weight loss alone, a measure of low muscularity alone or a combination of the two.
Journal ArticleDOI
Tenascin‐W, a new marker of cancer stroma, is elevated in sera of colon and breast cancer patients
Martin Degen,Florence Brellier,Susanne Schenk,Robert Driscoll,Khalil Zaman,Roger Stupp,Luigi Tornillo,Luigi Terracciano,Ruth Chiquet-Ehrismann,Curzio Rüegg,Walter Seelentag +10 more
TL;DR: The results reveal a clear association between elevated levels of tenascin‐W and the presence of cancer and warrant further studies to evaluate the potential value of serum and tissue tenascIn‐W levels as diagnostic, prognostic or monitoring biomarker in colorectal, breast and possibly other solid cancers.