R
Robert E. Strecker
Researcher at VA Boston Healthcare System
Publications - 131
Citations - 11114
Robert E. Strecker is an academic researcher from VA Boston Healthcare System. The author has contributed to research in topics: Sleep deprivation & Basal forebrain. The author has an hindex of 49, co-authored 128 publications receiving 10201 citations. Previous affiliations of Robert E. Strecker include Princeton University & Harvard University.
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Journal ArticleDOI
Adenosine: a mediator of the sleep-inducing effects of prolonged wakefulness.
Tarja Porkka-Heiskanen,Robert E. Strecker,Mahesh M. Thakkar,Alvhild Alette Bjørkum,Robert W. Greene,Robert W. McCarley +5 more
TL;DR: The data reported here suggest that the major criteria for a neural sleep factor mediating the somnogenic effects of prolonged wakefulness are satisfied by adenosine, a neuromodulator whose extracellular concentration increases with brain metabolism and which, in vitro, inhibits basal forebrain cholinergic neurons.
Journal ArticleDOI
Control of Sleep and Wakefulness
TL;DR: Genetic studies suggest that brain mechanisms controlling waking and NREM sleep are strongly conserved throughout evolution, underscoring their enormous importance for brain function.
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Adenosine and sleep–wake regulation
TL;DR: Evidence indicates that a cascade of signal transduction induced by basal forebrain adenosine A1 receptor activation in cholinergic neurons leads to increased transcription of the A1 receptors, which may play a role in mediating the longer-term effects of sleep deprivation.
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Brain site-specificity of extracellular adenosine concentration changes during sleep deprivation and spontaneous sleep: an in vivo microdialysis study.
TL;DR: The unique pattern of sleep-related changes in basal forebrain adenosine level lends strong support to the hypothesis that the sleep-promoting effects of adenosines, as well as the sleepiness associated with prolonged wakefulness, are both mediated by adenosinergic inhibition of a cortically projecting basal fore brain arousal system.
Journal ArticleDOI
Adenosinergic modulation of basal forebrain and preoptic/anterior hypothalamic neuronal activity in the control of behavioral state
Robert E. Strecker,Stephen Morairty,Mahesh M. Thakkar,Tarja Porkka-Heiskanen,Radhika Basheer,L. Dauphin,Donald G. Rainnie,C. M. Portas,Robert W. Greene,Robert W. McCarley +9 more
TL;DR: A growing body of evidence supports the role of AD as a mediator of the sleepiness following prolonged wakefulness, a role in which its inhibitory actions on the BF wakefulness-promoting neurons may be especially important.