R
Robert H. Lane
Researcher at Medical College of Wisconsin
Publications - 133
Citations - 6582
Robert H. Lane is an academic researcher from Medical College of Wisconsin. The author has contributed to research in topics: Offspring & DNA methylation. The author has an hindex of 42, co-authored 133 publications receiving 6057 citations. Previous affiliations of Robert H. Lane include Primary Children's Hospital & University of California, Los Angeles.
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Journal ArticleDOI
The developmental origins of adult disease
TL;DR: The subtle adjustments needed to ensure developmental plasticity in IUGR are provided by epigenetic modulation of critical genes, accompanied by changes in the quantity and activity of enzymes responsible for making modifications to chromatin as well as global and gene-specific modifications of chromatin.
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Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome
Kjersti Aagaard-Tillery,Kevin L. Grove,Jacalyn M. Bishop,Xingrao Ke,Qi Fu,Robert A. McKnight,Robert H. Lane +6 more
TL;DR: It is shown that a current significant in utero exposure (caloric-dense high-fat maternal diet) induces site-specific alterations in fetal hepatic H3 acetylation, and this results suggest that variations in the intrauterine environment in primates similarly induce changes in key determinants of hepatic chromatin structure.
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Uteroplacental insufficiency increases apoptosis and alters p53 gene methylation in the full-term IUGR rat kidney
Tho D. Pham,Nicole K. MacLennan,Christina T Chiu,Gisella S Laksana,Jennifer L. Hsu,Robert H. Lane +5 more
TL;DR: It is concluded that uteroplacental insufficiency alters p53 DNA CpG methylation, affects mRNA levels of key apoptosis-related proteins, increases renal apoptosis, and reduces glomeruli number in the IUGR kidney.
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Uteroplacental insufficiency alters DNA methylation, one-carbon metabolism, and histone acetylation in IUGR rats
Nicole K. MacLennan,S. Jill James,S Melnyk,Ali Piroozi,Stefanie Jernigan,Jennifer L. Hsu,Sara M. Janke,Tho D. Pham,Robert H. Lane +8 more
TL;DR: It is speculated that the altered intrauterine milieu associated with uteroplacental insufficiency affects hepatic one-carbon metabolism and subsequent DNA methylation, which thereby alters chromatin dynamics and leads to persistent changes in hepatic gene expression.
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Maternal obesity and high-fat diet program offspring metabolic syndrome.
Mina Desai,Mina Desai,Juanita K. Jellyman,Guang Han,Marie H. Beall,Robert H. Lane,Michael G. Ross,Michael G. Ross +7 more
TL;DR: Maternal obesity/HF diet has a marked impact on offspring body composition and the risk of metabolic syndrome was dependent on the period of exposure during pregnancy and/or lactation.