Robert Katzman

TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.

TL;DR: Both linear regressions and multivariate analyses correlating three global neuropsychological tests with a number of structural and neurochemical measurements performed on a prospective series of patients with Alzheimer's disease and 9 neuropathologically normal subjects reveal very powerful correlations with all three psychological assays.

TL;DR: A 6-item Orientation-Memory-Concentration Test has been validated as a measure of cognitive impairment and has been shown to discriminate among mild, moderate, and severe cognitive deficits.

TL;DR: Fourteen case histories of persons who had a histological diagnosis of either senile dementia of the Alzheimer type, multiinfarct dementia, or a mixed dementia composed of these two types and who showed evidence of a moderate to severe dementia on psychological testing were rated for the presence of thirteen clinical features comprising Hachinski's Ischemic Score.

TL;DR: The unexpected findings in these subjects were higher brain weights and greater number of neurons as compared to age‐matched nursing home control subjects, which suggest people may have had incipient Alzheimer's disease but escaped loss of large neurons, or started with larger brains and more large neurons and thus might be said to have had a greater reserve.