https://hal-pasteur.archives-ouvertes.fr/pasteur-01799353/document

TrackMate: An open and extensible platform for single-particle tracking.

Biocompatibility, Pharmaceutical and Biomedical Applications L. Harivardhan Reddy,†,‡ Jose ́ L. Arias, Julien Nicolas,† and Patrick Couvreur*,† †Laboratoire de Physico-Chimie, Pharmacotechnie et Biopharmacie, Universite ́ Paris-Sud XI, UMR CNRS 8612, Faculte ́ de Pharmacie, IFR 141, 5 rue Jean-Baptiste Cleḿent, F-92296 Chat̂enay-Malabry, France Departamento de Farmacia y Tecnología Farmaceútica, Facultad de Farmacia, Campus Universitario de Cartuja s/n, Universidad de Granada, 18071 Granada, Spain ‡Pharmaceutical Sciences Department, Sanofi, 13 Quai Jules Guesdes, F-94403 Vitry-sur-Seine, France

Magnetic nanoparticles: design and characterization, toxicity and biocompatibility, pharmaceutical and biomedical applications.

Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery

The properties of core–shell nanoparticles can be tuned so that they efficiently convert radiation into heat, leading to therapeutic results that are competitive with commercial drug treatments.

Exchange-coupled magnetic nanoparticles for efficient heat induction

Magnetic fluid hyperthermia: focus on superparamagnetic iron oxide nanoparticles.

HTSC bulk material which has been developed during the last ten years is now prepared in increasing quantities and used in demonstrators or prototypes of several applications, e.g., flywheels and motors. The quality control of large amounts of samples requires a method which is fast and provides essential information about the sample quality. In particular, the critical current density and its inhomogeneity should be determined. In this contribution we report about a trapped field measurement technique using pulsed field magnetization and field detection by a Hall-array. With this arrangement the required time of measurement is in the order of a few minutes per sample. The software which controls the devices contains also an analyzing procedure for the calculation of an effective critical current density as well as parameters describing the homogeneity of the samples.

A fast method of characterizing HTSC bulk material

When exposing nanomaterials, e.g. superparamagnetic iron oxide nanoparticles (SPIONs), to the peripheral blood, a protein corona consisting of various components is formed immediately. The composition of the corona as well as their amount bound to the particle surface is dependent on different factors, e.g. particle size and surface charge [1,2]. The actual composition of the formed protein corona might be of major importance for cellular uptake of magnetic nanoparticles [3, 4]. The aim of our experiments is to analyze the formation of the protein corona during in vitro serum incubation and to investigate the biocompatibility of such coated SPIONs.

Formation of a biocompatible protein corona on magnetic nanoparticles

The fabrication of biocompatible composites, consisting of magnetite nanoparticles embedded into a matrix of meltable dextran ester is presented which can be softened under an induced alternating magnetic field and may allow in that way a magnetically controlled release application. This could be a suitable alternative for swellable hydrogel composites embedded with magnetic particles as remote controlled biomaterial. Furthermore a texturing of particles in the polymer matrix by a static magnetic field was investigated.

Bio-nano composite for remote melting

Glass crystallization was used and further developed for preparation of micro- and nano- crystalline particulate oxide media of different compositions and with different properties. These media may find applications in high-density magnetic recording devices, in novel ferrofluids, in microwave devices, in glass-ceramic materials, as initial materials for composites and for biomedical purposes. The properties of these media and the performance of this method are discussed as well as its limitations.

Magnetic Oxide Particles Prepared by Glass Crystallization

Magnetic nanocomposites are a class of smart materials that have attracted recent interest as drug delivery systems or as medical implants. In this study, meltable nanobiocomposites (NBC) composed of biocompatible dextran fatty acid ester and magnetic nanoparticles (MNPs) melting close to human body temperature were prepared and loaded with Rhodamine B (RhB) or green fluorescent protein (GFP) as model drugs to evaluate their potential use as drug delivery system. The release of the model drugs from the magnetic NBC investigated under the influence of a high frequent alternating magnetic field (AMF, 20 kA/m at 400 kHz) showed that on-demand release is realized applying the external AMF. The NBC showed a long-term stability (28 d) of the incorporated iron oxide particles after incubation in artificial body fluids. This work reveals the potential of the NBC as a drug carrier.

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Robert Müller

Papers

A fast method of characterizing HTSC bulk material

Formation of a biocompatible protein corona on magnetic nanoparticles

Bio-nano composite for remote melting

Magnetic Oxide Particles Prepared by Glass Crystallization

Studies on the Controlled Release of Drugs from Magnetic Nanobiocomposites