R
Robert N. O'Meally
Researcher at Johns Hopkins University School of Medicine
Publications - 43
Citations - 3175
Robert N. O'Meally is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Phosphorylation & Proteome. The author has an hindex of 22, co-authored 38 publications receiving 2587 citations. Previous affiliations of Robert N. O'Meally include Johns Hopkins University.
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Journal ArticleDOI
The Plasma Proteome Identifies Expected and Novel Proteins Correlated with Micronutrient Status in Undernourished Nepalese Children
Robert N. Cole,Ingo Ruczinski,Kerry Schulze,Parul Christian,Shelley M. Herbrich,Lee Wu,Lauren R. DeVine,Robert N. O'Meally,Sudeep Shrestha,Tatiana Boronina,James D. Yager,John D. Groopman,Keith P. West +12 more
TL;DR: Plasma proteomics can identify and quantify protein biomarkers of micronutrient status in undernourished children, and individual proteins explained 34–77% of variation in their respective nutrient concentration by this strategy.
Journal ArticleDOI
Fatty acid synthase inhibits the O- GlcNAcase during oxidative stress
Jennifer Groves,Austin Maduka,Austin Maduka,Robert N. O'Meally,Robert N. Cole,Natasha E. Zachara +5 more
TL;DR: In this paper, the authors demonstrate that oxidative stress leads to elevated O-GlcNAc levels in U2OS cells but has little impact on the activity of OGT.
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Defective human MutY phosphorylation exists in colorectal cancer cell lines with wild-type MutY alleles.
Antony R. Parker,Robert N. O'Meally,Fikret Sahin,Gloria H. Su,Frederick K. Racke,William G. Nelson,Theodore L. DeWeese,James R. Eshleman +7 more
TL;DR: The authors showed that the defective repair of 8-oxoguanine (8-oxoG) mispairs was due to defective phosphorylation of the MutY protein in colorectal cancer cells.
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Phosphorylation of mutant huntingtin at serine 116 modulates neuronal toxicity.
Erin E. Watkin,Nicolas Arbez,Elaine Waldron-Roby,Robert N. O'Meally,Tamara Ratovitski,Robert N. Cole,Christopher A. Ross +6 more
TL;DR: The results suggest that S116 is a potential therapeutic target for Huntington's Disease, and indicate that the screening method is useful for identifying candidate phosphorylation sites.
Journal ArticleDOI
Combined Antibody/Lectin Enrichment Identifies Extensive Changes in the O-GlcNAc Sub-proteome upon Oxidative Stress
Albert Lee,Devin Miller,Roger Henry,Venkata D. P. Paruchuri,Robert N. O'Meally,Tatiana Boronina,Robert N. Cole,Natasha E. Zachara +7 more
TL;DR: Analysis of proteins with altered glycosylation suggests that stress-induced changes in O-GlcNAcylation cluster into pathways known to regulate the cell's response to injury and include protein folding, transcriptional regulation, epigenetics, and proteins involved in RNA biogenesis.