Robert N. O'Meally

TL;DR: Autoimmune responses to DNA topoisomerase I (topo I) are found in a subset of scleroderma patients who are at high risk for interstitial lung disease and mortality, and the frequency of HLA–DR–restricted topo I–specific CD4+ T cells is associated with the presence, severity, and progression of ILD.

TL;DR: Use of a novel natural antigen processing assay reveals a mechanism for the presentation of shared CD4+ T cell epitopes of topoisomerase-I in immunogenetically diverse patients with scleroderma.

TL;DR: In this article, the authors identify Ephexin5 as a key driver of hippocampal dysfunction and related behavioral deficits in Angelman syndrome (AS) mouse models, and they demonstrate the exciting potential of targeting EphexIN5, and possibly other UBE3A substrates, to improve symptoms of AS and other Ube3A-related developmental disorders.

TL;DR: It is reported that Ephexin5 is a direct substrate of UBE3A ubiquitin ligase activity and identified as a key driver of hippocampal dysfunction and related behavioral deficits in AS mouse models.

TL;DR: This work generates with high yield and purity exquisitely site specific and selective bio-conjugates of TNF-α by using amine reactive NHS ester chemistry and confirms the N terminal selectivity and specificity.