Wendy Xin

TL;DR: Recent work characterizing plasticity in the oligodendrocyte lineage following sensory experience and learning is summarized, the physiological and behavioural consequences of manipulating that plasticity are summarized, and the evidence for oligodendsia and myelin dysfunction in neurodevelopmental disorders with cognitive symptoms is discussed.

TL;DR: In this article, the authors characterized the dynamics of myelin generation and loss in the APP/PS1 mouse model of Alzheimer's disease and observed a dramatic increase in the rate of new myelin formation.

TL;DR: Using a combination of whole-transcriptome sequencing, histology, slice electrophysiology, and calcium imaging, this work performs the first functional and molecular profiling of ventral midbrain astrocytes and observed numerous differences between these cells and their telencephalic counterparts, both in their gene expression profile and in their physiological properties.

TL;DR: It is shown that oligodendrocytes, the myelinating glia of the central nervous system, also express high levels of GS in caudal regions like the midbrain and the spinal cord and may represent a therapeutic target for pathological conditions related to brain glutamate dysregulation.

TL;DR: Recent findings on astrocyte heterogeneity are summarized and the implications for their interactions with neurons and their effects on neuronal transmission are discussed.