R
Robert Steele
Researcher at University of Dundee
Publications - 519
Citations - 24225
Robert Steele is an academic researcher from University of Dundee. The author has contributed to research in topics: Cancer & Colorectal cancer. The author has an hindex of 74, co-authored 492 publications receiving 21963 citations. Previous affiliations of Robert Steele include Harvard University & NHS Tayside.
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Length of Barrett's oesophagus: an important factor in the development of dysplasia and adenocarcinoma.
TL;DR: Length of columnar lined oesophagus seems to be a significant risk factor in the development of dysplasia and subsequent carcinoma and intensive follow up of patients with columnarlined oesphagus greater than 8 cm in length is recommended.
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Spindle Orientation Bias in Gut Epithelial Stem Cell Compartments Is Lost in Precancerous Tissue
A. J. Quyn,Paul L. Appleton,Francis A. Carey,Robert Steele,Nick Barker,Hans Clevers,Rachel A. Ridgway,Owen J. Sansom,Inke S. Näthke +8 more
TL;DR: In this article, the authors demonstrate alignment of mitotic spindles perpendicular to the apical surface specifically in the stem cell compartments of mouse and human intestine and colon and suggest that loss of asymmetric division in stem cells might contribute to the oncogenic effect of Apc mutations in gut epithelium.
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Results of the first round of a demonstration pilot of screening for colorectal cancer in the United Kingdom
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The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma
TL;DR: The data indicate that the presence of K-ras mutations predicts poor patient prognosis in colorectal cancer, independently of tumour stage.