R
Robert T. Sauer
Researcher at Massachusetts Institute of Technology
Publications - 408
Citations - 42127
Robert T. Sauer is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Repressor & Protein degradation. The author has an hindex of 106, co-authored 402 publications receiving 40181 citations. Previous affiliations of Robert T. Sauer include University of California, San Francisco & Harvard University.
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Journal ArticleDOI
Deciphering the message in protein sequences: tolerance to amino acid substitutions
TL;DR: Comparison of different sequences with similar messages can reveal key features of the code and improve understanding of how a protein folds and how it performs its function.
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Protein-DNA Recognition
Carl O. Pabo,Robert T. Sauer +1 more
TL;DR: The current models for the complexes of Cro, repressor, and CAP with operator DNA are probably fundamentally correct, but it should be emphasized that model building alone, even when coupled with genetic and biochemical studies, cannot be expected to provide a completely reliable "high-resolution" view of the protein-DNA complex.
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Transcription factors: structural families and principles of DNA recognition
Carl O. Pabo,Robert T. Sauer +1 more
TL;DR: Familiarity, ease of access, trust, and awareness of benefits and risks to minimize uncertainty, will all be important for the sustained support of existing and new generations of DNA-B isolaters.
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Role of a Peptide Tagging System in Degradation of Proteins Synthesized from Damaged Messenger RNA
TL;DR: Variants of λ repressor and cytochrome b562 translated from messenger RNAs without stop codons were modified by carboxyl terminal addition of an ssrA-encoded peptide tag and subsequently degraded by car boxyl terminal-specific proteases present in both the cytoplasm and periplasm of Escherichia coli.
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The ClpXP and ClpAP proteases degrade proteins with carboxy-terminal peptide tails added by the SsrA-tagging system
TL;DR: Having diverse degradation systems able to recognize this tag may increase degradation capacity, permit degradation of a wide variety of different tagged proteins, or allow SsrA-tagged proteins to be degraded under different growth conditions.