R
Robert V. Stick
Researcher at University of Western Australia
Publications - 197
Citations - 3894
Robert V. Stick is an academic researcher from University of Western Australia. The author has contributed to research in topics: Acarbose & Catalysis. The author has an hindex of 31, co-authored 197 publications receiving 3727 citations. Previous affiliations of Robert V. Stick include University College West & Centre national de la recherche scientifique.
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Journal ArticleDOI
Halide ion catalyzed glycosidation reactions. Syntheses of .alpha.-linked disaccharides
Journal ArticleDOI
An efficient, inexpensive, and shelf-stable diazotransfer reagent: imidazole-1-sulfonyl azide hydrochloride.
TL;DR: The design and synthesis of a new diazotransfer reagent, imidazole-1-sulfonyl azide hydrochloride, are reported, which has proven to equal triflyl azides in its ability to act as a "diazo donor" in the conversion of both primary amines into azides and activated methylene substrates into diazo compounds.
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Iminosugar glycosidase inhibitors: structural and thermodynamic dissection of the binding of isofagomine and 1-deoxynojirimycin to beta-glucosidases.
David L. Zechel,A.B. Boraston,Tracey M. Gloster,Catherine M. Boraston,James M. MacDonald,D. Matthew G. Tilbrook,Robert V. Stick,Gideon J. Davies +7 more
TL;DR: The binding of 1-deoxynojirimycin and (+)-isofagomine to the "family GH-1" beta-glucosidase of Thermotoga maritima is investigated by kinetic analysis, isothermal titration calorimetry, and X-ray crystallography, finding that the binding of both of these iminosugar inhibitors is driven by a large and favorable enthalpy.
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Glycosidase Inhibition: An Assessment of the Binding of 18 Putative Transition-State Mimics.
Tracey M. Gloster,Peter J. Meloncelli,Robert V. Stick,David L. Zechel,and Andrea Vasella,Gideon J. Davies +5 more
TL;DR: A synergistic approach for analysis of inhibitors with a single enzyme 'model system', the Thermotoga maritima family 1 beta-glucosidase, TmGH1, allowing the characterization of 18 compounds, all putative transition-state mimics, in order to build an 'inhibition profile' that provides an insight into what governs binding.
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Synthesis and Use of Mechanism-Based Protein-Profiling Probes for Retaining β-D-Glucosaminidases Facilitate Identification of Pseudomonas aeruginosa NagZ
Keith A. Stubbs,Adrian Scaffidi,Aleksandra W. Debowski,Brian L. Mark,Robert V. Stick,David J. Vocadlo +5 more
TL;DR: The concise synthesis of 2-azidoacetyl-2-deoxy-5-fluoro-beta-d-glucopyranosyl fluoride is described as an activity-based proteomics probe for profiling these exo-glycosidases and may prove to be of general use for profiling proteomes and identifying glycoside hydrolases of medical importance or having desirable properties for biotechnology.