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Roberto Fabiani
Researcher at University of Perugia
Publications - 66
Citations - 2831
Roberto Fabiani is an academic researcher from University of Perugia. The author has contributed to research in topics: Hydroxytyrosol & Comet assay. The author has an hindex of 27, co-authored 61 publications receiving 2402 citations.
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Journal ArticleDOI
Phenolic compounds in olive oil: antioxidant, health and organoleptic activities according to their chemical structure.
Maurizio Servili,Sonia Esposto,Roberto Fabiani,Stefania Urbani,Agnese Taticchi,F. Mariucci,Roberto Selvaggini,GianFrancesco Montedoro +7 more
TL;DR: Hydrophilic phenols are the most abundant natural antioxidants of virgin olive oil, in which, however, tocopherols and carotenes are also present.
Journal ArticleDOI
Cancer chemoprevention by hydroxytyrosol isolated from virgin olive oil through G1 cell cycle arrest and apoptosis.
Roberto Fabiani,A. De Bartolomeo,Patrizia Rosignoli,Maurizio Servili,GianFrancesco Montedoro,Guido Morozzi +5 more
TL;DR: The hypothesis that hydroxytyrosol may exert a protective activity against cancer by arresting the cell cycle and inducing apoptosis in tumour cells is supported and hydroxyTYrosol, an important component of virgin olive oil, may be responsible for its anticancer activity is suggested.
Journal ArticleDOI
Oxidative DNA Damage Is Prevented by Extracts of Olive Oil, Hydroxytyrosol, and Other Olive Phenolic Compounds in Human Blood Mononuclear Cells and HL60 Cells
Roberto Fabiani,Patrizia Rosignoli,Angelo De Bartolomeo,Raffaela Fuccelli,Maurizio Servili,Gian Francesco Montedoro,Guido Morozzi +6 more
TL;DR: The results suggest that OO-PE and WW-PE may efficiently prevent the initiation step of carcinogenesis in vivo, because the concentrations effective against the oxidative DNA damage could be easily reached with normal intake of olive oil.
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Virgin Olive Oil Phenols Inhibit Proliferation of Human Promyelocytic Leukemia Cells (HL60) by Inducing Apoptosis and Differentiation
Roberto Fabiani,Angelo De Bartolomeo,Patrizia Rosignoli,Maurizio Servili,Roberto Selvaggini,Gian Francesco Montedoro,Cristina Di Saverio,Guido Morozzi +7 more
TL;DR: The hypothesis that polyphenols play a critical role in the anticancer activity of olive oil is supported, as demonstrated by the effect of a virgin olive oil phenol extract on proliferation, the cell cycle distribution profile, apoptosis, and differentiation of the human promyelocytic cell line HL60.
Journal ArticleDOI
Nutrigenomics of extra-virgin olive oil: A review.
Marta Piroddi,Adriana Albini,Roberto Fabiani,Lisa Giovannelli,Cristina Luceri,Fausta Natella,Patrizia Rosignoli,Teresa Rossi,Agnese Taticchi,Maurizio Servili,Francesco Galli +10 more
TL;DR: Gene regulation properties of the functional components of olive oil, such as oleic acid, biophenols and vitamin E, point to a role for these molecules as natural homeostatic and even hormetic factors with applications as prevention agents in conditions of premature and pathologic aging.