Roberto Fabiani

TL;DR: Hydrophilic phenols are the most abundant natural antioxidants of virgin olive oil, in which, however, tocopherols and carotenes are also present.

TL;DR: The hypothesis that hydroxytyrosol may exert a protective activity against cancer by arresting the cell cycle and inducing apoptosis in tumour cells is supported and hydroxyTYrosol, an important component of virgin olive oil, may be responsible for its anticancer activity is suggested.

TL;DR: The results suggest that OO-PE and WW-PE may efficiently prevent the initiation step of carcinogenesis in vivo, because the concentrations effective against the oxidative DNA damage could be easily reached with normal intake of olive oil.

TL;DR: The hypothesis that polyphenols play a critical role in the anticancer activity of olive oil is supported, as demonstrated by the effect of a virgin olive oil phenol extract on proliferation, the cell cycle distribution profile, apoptosis, and differentiation of the human promyelocytic cell line HL60.

TL;DR: Gene regulation properties of the functional components of olive oil, such as oleic acid, biophenols and vitamin E, point to a role for these molecules as natural homeostatic and even hormetic factors with applications as prevention agents in conditions of premature and pathologic aging.