R
Roberto Rodríguez-Labrada
Researcher at University of Holguín
Publications - 69
Citations - 1370
Roberto Rodríguez-Labrada is an academic researcher from University of Holguín. The author has contributed to research in topics: Spinocerebellar ataxia & Ataxia. The author has an hindex of 19, co-authored 63 publications receiving 1081 citations.
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Journal ArticleDOI
Familial Alzheimer’s disease–associated presenilin-1 alters cerebellar activity and calcium homeostasis
Diego Sepulveda-Falla,Alvaro Barrera-Ocampo,Christian Hagel,Anne Korwitz,María Fernanda Vinueza-Veloz,Kuikui Zhou,Martijn Schonewille,Haibo Zhou,Luis Velázquez-Pérez,Roberto Rodríguez-Labrada,Andrés Villegas,Isidro Ferrer,Francisco Lopera,Thomas Langer,Chris I. De Zeeuw,Markus Glatzel +15 more
TL;DR: It is proposed that PS1-E280A affects both Ca2+ homeostasis and Aβ precursor processing, leading to FAD and neurodegeneration.
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A Comprehensive Review of Spinocerebellar Ataxia Type 2 in Cuba
Luis Velázquez-Pérez,Roberto Rodríguez-Labrada,Julio Cesar García-Rodríguez,Luis E. Almaguer-Mederos,Tania Cruz-Mariño,José Miguel Laffita-Mesa +5 more
TL;DR: The comprehensive characterization reached in Cuba through clinical, neuroepidemiological, neurochemical, and neurophysiological evaluation of SCA2 patients and pre-symptomatic subjects, which has allowed the identification of new disease biomarkers and therapeutical opportunities are highlighted.
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Saccade velocity is reduced in presymptomatic spinocerebellar ataxia type 2
Luis Velázquez-Pérez,Carola Seifried,M. Abele,F. Wirjatijasa,Roberto Rodríguez-Labrada,N. Santos-Falcón,Sánchez-Cruz G,Luis E. Almaguer-Mederos,R. Tejeda,Nalia Canales-Ochoa,Michael Fetter,Ulf Ziemann,Thomas Klockgether,Jacqueline Medrano-Montero,Julio Cesar Rodríguez-Díaz,José Miguel Laffita-Mesa,Georg Auburger +16 more
TL;DR: Saccade velocity is a sensitive SCA2 endophenotype that reflects early pontine degeneration and may be a useful diagnostic parameter before the onset of ataxia.
Journal ArticleDOI
Progression of early features of spinocerebellar ataxia type 2 in individuals at risk: a longitudinal study
Luis Velázquez-Pérez,Roberto Rodríguez-Labrada,Nalia Canales-Ochoa,Jacqueline Medrano Montero,Sánchez-Cruz G,Raúl Aguilera-Rodríguez,Luis E. Almaguer-Mederos,José Miguel Laffita-Mesa +7 more
TL;DR: Early features of SCA2 are detectable before the onset of the cerebellar syndrome, and are associated with expanded CAG repeats and the time to onset of cerebellary syndrome.
Journal ArticleDOI
Spinocerebellar Ataxia Type 2: Clinicogenetic Aspects, Mechanistic Insights, and Management Approaches
TL;DR: Neuropathological investigations of brain tissue from SCA2 patients reveal a widespread involvement of multiple brain systems, mainly cerebellar and brainstem systems, and insights into the ataxin-2-related toxicity mechanism in neurodegenerative diseases are provided.