M
Markus Glatzel
Researcher at University of Hamburg
Publications - 307
Citations - 17180
Markus Glatzel is an academic researcher from University of Hamburg. The author has contributed to research in topics: Medicine & Disease. The author has an hindex of 57, co-authored 273 publications receiving 13094 citations. Previous affiliations of Markus Glatzel include University of Zurich & University of Ulm.
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Journal ArticleDOI
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
Susanne Krasemann,Susanne Krasemann,Charlotte Madore,Ron Cialic,Caroline Baufeld,Narghes Calcagno,Rachid El Fatimy,Lien Beckers,Elaine O’Loughlin,Yang Xu,Zain Fanek,David J. Greco,Scott T. Smith,George Tweet,Zachary Humulock,Tobias Zrzavy,Patricia Conde-Sanroman,Mar Gacias,Zhiping Weng,Hao Chen,Emily C. Tjon,Fargol Mazaheri,Kristin Hartmann,Asaf Madi,Jason D. Ulrich,Markus Glatzel,Anna Worthmann,Joerg Heeren,Bogdan Budnik,Cynthia A. Lemere,Tsuneya Ikezu,Frank L. Heppner,Vladimir Litvak,David M. Holtzman,Hans Lassmann,Howard L. Weiner,Jordi Ochando,Christian Haass,Oleg Butovsky +38 more
TL;DR: The TREM2-APOE pathway is identified as a major regulator of microglial functional phenotype in neurodegenerative diseases and serves as a novel target that could aid in the restoration of homeostatic microglia.
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Multiorgan and Renal Tropism of SARS-CoV-2.
Victor G. Puelles,Marc Lütgehetmann,Maja T. Lindenmeyer,Jan Sperhake,Milagros N. Wong,Lena Allweiss,Silvia Chilla,Axel Heinemann,Nicola Wanner,Shuya Liu,Fabian Braun,Shun Lu,Susanne Pfefferle,Ann Sophie Schröder,Carolin Edler,Oliver Gross,Markus Glatzel,Dominic Wichmann,Thorsten Wiech,Stefan Kluge,Klaus Pueschel,Martin Aepfelbacher,Tobias B. Huber +22 more
TL;DR: In this autopsy series, the authors found that SARS-CoV-2 has an organotropism beyond the respiratory tract, including the kidneys, heart, liver, and brai...
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Neuropathology of patients with COVID-19 in Germany: a post-mortem case series.
Jakob Matschke,Marc Lütgehetmann,Christian Hagel,Jan Sperhake,Ann Sophie Schröder,Carolin Edler,Herbert Mushumba,Antonia Fitzek,Lena Allweiss,Maura Dandri,Matthias Dottermusch,Axel Heinemann,Susanne Pfefferle,Marius Schwabenland,Daniel Sumner Magruder,Stefan Bonn,Stefan Bonn,Marco Prinz,Christian Gerloff,Klaus Püschel,Susanne Krasemann,Martin Aepfelbacher,Markus Glatzel +22 more
TL;DR: In general, neuropathological changes in patients with COVID-19 seem to be mild, with pronounced neuroinflammatory changes in the brainstem being the most common finding, and there was no evidence for CNS damage directly caused by SARS-CoV-2.
Journal ArticleDOI
Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke
Yang-Wei Fann,S-Y Lee,Silvia Manzanero,Sung-Chun Tang,Mathias Gelderblom,Prasad Chunduri,Christian Bernreuther,Markus Glatzel,Yi-Lin Cheng,John Thundyil,Alexander Widiapradja,Ker Zhing Lok,S L Foo,Y-C Wang Wang,Y-I Li,Grant R Drummond,Milan Basta,Tim Magnus,Dong-Gyu Jo,Mark P. Mattson,Christopher G. Sobey,Thiruma V. Arumugam,Thiruma V. Arumugam,Thiruma V. Arumugam +23 more
TL;DR: Evidence is provided that the NLRP1 and NLRP3 inflammasomes have a major role in neuronal cell death and behavioral deficits in stroke, and that IVIg treatment can protect brain cells against ischemic damage, suggesting a potential clinical benefit of therapeutic interventions that targetinflammasome assembly and activity.
Journal ArticleDOI
Genetic prion disease: the EUROCJD experience.
Gabor G. Kovacs,Maria Puopolo,Anna Ladogana,Maurizio Pocchiari,Herbert Budka,Cornelia M. van Duijn,Steven J. Collins,Alison Boyd,Antonio Giulivi,Mike Coulthart,N. Delasnerie-Laupretre,Jean Philippe Brandel,Inga Zerr,Hans A. Kretzschmar,Jesús de Pedro-Cuesta,Miguel Calero-Lara,Markus Glatzel,Adriano Aguzzi,Matthew Bishop,Richard Knight,Girma Belay,Robert G. Will,Eva Mitrova +22 more
TL;DR: The authors' results show that clinicopathological phenotypes include genetic Creutzfeldt–Jakob disease (gCJD), fatal familial insomnia (FFI), and Gerstmann–Sträussler–Scheinker disease (GSS).