R
Robin D. Hatton
Researcher at University of Alabama at Birmingham
Publications - 31
Citations - 14047
Robin D. Hatton is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: T cell & Transcription factor. The author has an hindex of 22, co-authored 27 publications receiving 13039 citations.
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Journal ArticleDOI
Interleukin 17–producing CD4 + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
Laurie E. Harrington,Robin D. Hatton,Paul R. Mangan,Henrietta Turner,Theresa L. Murphy,Kenneth M. Murphy,Casey T. Weaver +6 more
TL;DR: Findings provide a basis for understanding how inhibition of IFN-γ signaling enhances development of pathogenic TH-17 effector cells that can exacerbate autoimmunity.
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Transforming growth factor-beta induces development of the T(H)17 lineage.
Paul R. Mangan,Laurie E. Harrington,Darrell B. O'Quinn,Whitney S. Helms,Daniel C. Bullard,Charles O. Elson,Robin D. Hatton,Sharon M. Wahl,Trenton R. Schoeb,Casey T. Weaver +9 more
TL;DR: This article identified transforming growth factor-beta (TGF-beta) as a cytokine critical for commitment to Thelper-17 (T(H)17) development, which is required for host protection against a bacterial pathogen, Citrobacter rodentium.
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IL-17 Family Cytokines and the Expanding Diversity of Effector T Cell Lineages
TL;DR: The factors that specify differentiation of a new effector T cell lineage-Th17-have now been identified, providing a new arm of adaptive immunity and presenting a unifying model that can explain many heretofore confusing aspects of immune regulation, immune pathogenesis, and host defense.
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Reciprocal Interactions of the Intestinal Microbiota and Immune System
TL;DR: Understanding how the adaptive immune system copes with the remarkable number and diversity of microbes that colonize the digestive tract, and how the system integrates with more primitive innate immune mechanisms to maintain immune homeostasis, holds considerable promise for new approaches to modulate immune networks to treat and prevent disease.
Journal ArticleDOI
The AP-1 transcription factor Batf controls TH17 differentiation
Barbara U. Schraml,Kai Hildner,Wataru Ise,Wan-Ling Lee,Whitney A.-E. Smith,Ben Solomon,Gurmukh Sahota,Julia Sim,Ryuta Mukasa,Saso Cemerski,Robin D. Hatton,Gary D. Stormo,Casey T. Weaver,John H. Russell,Theresa L. Murphy,Kenneth M. Murphy +15 more
TL;DR: It is shown that Batf is required for the differentiation of IL17-producing T helper (TH17) cells, and it is demonstrated that the AP-1 protein BATF has a critical role in TH17 differentiation.