G
Gurmukh Sahota
Researcher at University of Pennsylvania
Publications - 11
Citations - 1117
Gurmukh Sahota is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Atrial fibrillation & Left atrial appendage occlusion. The author has an hindex of 6, co-authored 10 publications receiving 1045 citations. Previous affiliations of Gurmukh Sahota include Washington University in St. Louis & University of Illinois at Urbana–Champaign.
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Journal ArticleDOI
The AP-1 transcription factor Batf controls TH17 differentiation
Barbara U. Schraml,Kai Hildner,Wataru Ise,Wan-Ling Lee,Whitney A.-E. Smith,Ben Solomon,Gurmukh Sahota,Julia Sim,Ryuta Mukasa,Saso Cemerski,Robin D. Hatton,Gary D. Stormo,Casey T. Weaver,John H. Russell,Theresa L. Murphy,Kenneth M. Murphy +15 more
TL;DR: It is shown that Batf is required for the differentiation of IL17-producing T helper (TH17) cells, and it is demonstrated that the AP-1 protein BATF has a critical role in TH17 differentiation.
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Magic-Angle Spinning Solid-State NMR Spectroscopy of the β1 Immunoglobulin Binding Domain of Protein G (GB1): 15N and 13C Chemical Shift Assignments and Conformational Analysis
W. Trent Franks,Donghua H. Zhou,Benjamin J. Wylie,Brian G. Money,Daniel T. Graesser,Heather L. Frericks,Gurmukh Sahota,Chad M. Rienstra +7 more
TL;DR: Main isotropic chemical shifts report on conformation, enabling a detailed comparison of the microcrystalline state with the conformation of single crystals and the protein in solution; the consistency of backbone conformation is the best among proteins studied so far.
Journal ArticleDOI
Regulation of the Drosophila Enhancer of split and invected-engrailed gene complexes by sister chromatid cohesion proteins
Cheri A. Schaaf,Ziva Misulovin,Gurmukh Sahota,Akbar M. Siddiqui,Yuri B. Schwartz,Tatyana G. Kahn,Vincenzo Pirrotta,Maria Gause,Dale Dorsett +8 more
TL;DR: It is shown that transcription is hypersensitive to cohesin levels in two exceptional cases where cohesIn and the E(z)-mediated histone methylation simultaneously coat the entire Enhancer of split and invected-engrailed gene complexes in cells derived from Drosophila central nervous system.
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Bisphosphonate inhibitors of Toxoplasma gondi growth: in vitro, QSAR, and in vivo investigations.
Yan Ling,Gurmukh Sahota,Sarah Odeh,Julian M. W. Chan,Fausto G. Araujo,Silvia N.J. Moreno,Silvia N.J. Moreno,Eric Oldfield +7 more
TL;DR: The three most active compounds found in vitro were tested in vivo in a Smith-Webster mouse model and the two most active bisphosphonates were found to provide up to an 80% protection from death, a considerable improvement over that found previously with nitrogen-containing bisph phosphate compounds.
Journal ArticleDOI
Novel sequence-based method for identifying transcription factor binding sites in prokaryotic genomes
Gurmukh Sahota,Gary D. Stormo +1 more
TL;DR: This work has developed a method that will primarily use available sequence data in order to determine prokaryotic transcription factor (TF) binding specificities and found putative motifs within each separate class.