R
Robin E. Duncan
Researcher at University of Waterloo
Publications - 63
Citations - 3802
Robin E. Duncan is an academic researcher from University of Waterloo. The author has contributed to research in topics: Lipolysis & Adipose tissue. The author has an hindex of 24, co-authored 54 publications receiving 3291 citations. Previous affiliations of Robin E. Duncan include University of Toronto & University of California, Berkeley.
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Journal ArticleDOI
Regulation of lipolysis in adipocytes.
TL;DR: This review provides an overview of key mediators of lipolysis and the regulation of this process by changes in nutritional status and nutrient intakes.
Journal ArticleDOI
Desnutrin/ATGL Is Regulated by AMPK and Is Required for a Brown Adipose Phenotype
Maryam Ahmadian,Marcia J. Abbott,Tianyi Tang,Carolyn S.S. Hudak,Yangha Kim,Matthew D. Bruss,Marc K. Hellerstein,Hui-Young Lee,Varman T. Samuel,Gerald I. Shulman,Yuhui Wang,Robin E. Duncan,Chulho Kang,Hei Sook Sul +13 more
TL;DR: Overall, desnutrin is phosphorylated/activated by AMPK to increase lipolysis and brings FA oxidation and UCP-1 induction for thermogenesis and despite adiposity and impaired BAT function, desnutsrin-ASKO mice have improved hepatic insulin sensitivity with lower DAG levels.
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Regulation of triglyceride metabolism. IV. Hormonal regulation of lipolysis in adipose tissue.
TL;DR: Intricate cooperation of these endocrine and autocrine/paracrine factors leads to a fine regulation of lipolysis in adipocytes, needed for energy homeostasis.
Journal ArticleDOI
AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency.
Kathy Jaworski,Maryam Ahmadian,Robin E. Duncan,Eszter Sarkadi-Nagy,Krista A. Varady,Marc K. Hellerstein,Hui-Young Lee,Varman T. Samuel,Gerald I. Shulman,Kee Hong Kim,Sarah De Val,Chulho Kang,Hei Sook Sul +12 more
TL;DR: The role of the newly identified major adipocyte phospholipase A2, AdPLA (encoded by Pla2g16, also called HREV107), in the regulation of lipolysis and adiposity is described and is crucial for the development of obesity.
Journal ArticleDOI
Adipose Overexpression of Desnutrin Promotes Fatty Acid Use and Attenuates Diet-Induced Obesity
Maryam Ahmadian,Robin E. Duncan,Krista A. Varady,Danúbia Frasson,Marc K. Hellerstein,Andreas L. Birkenfeld,Varman T. Samuel,Gerald I. Shulman,Yuhui Wang,Chulho Kang,Hei Sook Sul +10 more
TL;DR: It is shown that by increasing lipolysis, desnutrin overexpression causes reduced adipocyte TAG content and attenuation of diet-induced obesity and promotes fatty acid oxidation and re-esterification within adipocytes.