Rocío Pérez-González

TL;DR: It is hypothesized that the exosome secretory pathway plays a pleiotropic role in the brain:Exosome secretion is beneficial to the cell, acting as a specific releasing system of neurotoxic APP CTFs and Aβ, but the secretion of exosomes enriched with APP C TFs, neurotoxic proteins that are also a source of secreted Aβ is harmful to the brain.

TL;DR: Using a high-resolution density gradient separation of extracellular vesicles (EVs) isolated from murine and human DS and diploid control brains, this paper identified and characterized a previously unknown population of double-membraned EVs containing multiple mitochondrial proteins distinct from previously described EV subtypes, including microvesicles and exosomes.

TL;DR: It is suggested that in AβPP/PS1 mice, leptin exerts changes resembling acute neurotrophic and neuroprotective effects, which could serve as the basis for the design of future treatment strategies in AD.

TL;DR: It is found that exosome secretion is enhanced in the brains of DS patients and a mouse model of the disease, and by DS fibroblasts, and increased levels of the tetraspanin CD63, a regulator ofExosome biogenesis, were observed in DS brains, suggesting the upregulation of exosomes represents a potential therapeutic goal for neurodegenerative disorders with endosomal pathology.

TL;DR: Current data show that the TaqIA polymorphism may be a marker of both DRD2 and ANKK1 genetic variants, which raises the question of whether signaling players intervene in the pathophysiology of psychiatric disorders.