Journal ArticleDOI
The ANKK1 kinase gene and psychiatric disorders.
Guillermo Ponce,Rocío Pérez-González,M. Aragues,Tomás Palomo,R. Rodriguez-Jimenez,Miguel Ángel Jiménez-Arriero,Janet Hoenicka +6 more
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TLDR
Current data show that the TaqIA polymorphism may be a marker of both DRD2 and ANKK1 genetic variants, which raises the question of whether signaling players intervene in the pathophysiology of psychiatric disorders.Abstract:
The TaqIA single nucleotide polymorphism (SNP, rs1800497), which is located in the gene that codes for the putative kinase ANKK1 (ANKK1) near the termination codon of the D2 dopamine receptor gene (DRD2; chromosome 11q22-q23), is the most studied genetic variation in a broad range of psychiatric disorders and personality traits. A large number of individual genetic association studies have found that the TaqIA SNP is linked to alcoholism and antisocial traits. In addition, it has also been related to other conditions such as schizophrenia, eating disorders, and some behavioral childhood disorders. The TaqIA A1 allele is mainly associated with addictions, antisocial disorders, eating disorders, and attention-deficit/hyperactivity disorders, while the A2 allele occurs more frequently in schizophrenic and obsessive-compulsive patients. Current data show that the TaqIA polymorphism may be a marker of both DRD2 and ANKK1 genetic variants. ANKK1 would belong to a family of kinases involved in signal transduction. This raises the question of whether signaling players intervene in the pathophysiology of psychiatric disorders. Basic research on the ANKK1 protein and its putative interaction with the D2 dopamine receptor could shed light on this issue.read more
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Relation Between Obesity and Blunted Striatal Response to Food Is Moderated by TaqIA A1 Allele
Michelle D. Wang,H. Yin,R. Landick,J. Gelles,L. S. Churchman,Z. Okten,R. S. Rock,J. F. Dawson,J. A. Spudich,C. G. Baumann,S. B. Smith,V. A. Bloomfield,C. Bustamante,A. R. Dunn,D. R. Halpin,D. Herschlag,W. L. Martin,B. H. Robinson,J. M. Schurr,A. L. Smith,R. M. Weisinger,S. J. Wrenn,Y. Bai,S. Doniach,K. Ito,J. Lipfert,I. S. Millett,S. Seifert,P. Thiyagarajan,H. Tsuruta +29 more
Journal ArticleDOI
Circadian Clock Gene Polymorphisms in Alcohol Use Disorders and Alcohol Consumption
Leena Kovanen,Sirkku T. Saarikoski,Jari Haukka,Sami Pirkola,Sami Pirkola,Arpo Aromaa,Jouko Lönnqvist,Jouko Lönnqvist,Timo Partonen +8 more
TL;DR: In this article, the authors investigated whether circadian clock gene polymorphisms predispose to alcohol dependence or abuse or other alcohol-related characteristics and found that the role of DRD2 and NPY on alcohol dependence was also supported.
Circadian Clock Gene Polymorphisms in Alcohol Use Disorders and Alcohol Consumption
Leena Kovanen,Sirkku T. Saarikoski,Jari Haukka,Sami Pirkola,Sami Pirkola,Arpo Aromaa,Jouko Lönnqvist,Jouko Lönnqvist,Timo Partonen +8 more
TL;DR: ARNTL, ARNTL2, VIP and ADCYAP1 were indicated as having influence on alcohol use or abuse and the role of DRD2 and NPY on alcohol dependence was supported.
Journal ArticleDOI
Common single nucleotide variants underlying drug addiction: more than a decade of research.
Kora-Mareen Bühler,Elena Giné,Victor Echeverry-Alzate,Javier Calleja-Conde,Fernando Rodríguez de Fonseca,José Antonio López-Moreno +5 more
TL;DR: SNPs in the alcohol metabolizing genes, in the cholinergic gene cluster CHRNA5‐CHRNA3‐CHRNB4, and in the DRD2 and ANNK1 genes, are, to date, the most replicated and significant gene variants associated with alcohol‐ and nicotine‐related phenotypes.
Journal ArticleDOI
Behavioral genetics in antisocial spectrum disorders and psychopathy: a review of the recent literature.
TL;DR: Some of the recent molecular genetics work concerning antisocial spectrum disorders and psychopathy is summarized, with a focus on genes involved in the serotonergic and dopaminergic pathways, while also mentioning some of the novel genetic factors being considered.
References
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Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
G. Di Chiara,Assunta Imperato +1 more
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Journal ArticleDOI
Allelic association of human dopamine D2 receptor gene in alcoholism.
Kenneth Blum,Ernest P. Noble,Peter J. Sheridan,Anne Montgomery,Terry Ritchie,Pudur Jagadeeswaran,Harou Nogami,Arthur H. Briggs,Jay B. Cohn +8 more
TL;DR: The polymorphic pattern of this receptor gene suggests that a gene that confers susceptibility to at least one form of alcoholism is located on the q22-q23 region of chromosome 11.
Journal ArticleDOI
Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor
Jubao Duan,Mark S. Wainwright,Josep M. Comeron,Naruya Saitou,Alan R. Sanders,Joel Gelernter,Pablo V. Gejman +6 more
TL;DR: Some synonymous mutations in the human DRD2 have functional effects and suggest a novel genetic mechanism, calling into question some assumptions made about synonymous variation in molecular population genetics and gene-mapping studies of diseases with complex inheritance, and indicate that synonymous variation can have effects of potential pathophysiological and pharmacogenetic importance.
Journal ArticleDOI
Relation Between Obesity and Blunted Striatal Response to Food Is Moderated by TaqIA A1 Allele
TL;DR: Cross-sectional and prospective data from two functional magnetic resonance imaging studies support the hypothesis that individuals may overeat to compensate for a hypofunctioning dorsal striatum, particularly those with genetic polymorphisms thought to attenuate dopamine signaling in this region.