抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

We review evidence for partially segregated networks of brain areas that carry out different attentional functions. One system, which includes parts of the intraparietal cortex and superior frontal cortex, is involved in preparing and applying goal-directed (top-down) selection for stimuli and responses. This system is also modulated by the detection of stimuli. The other system, which includes the temporoparietal cortex and inferior frontal cortex, and is largely lateralized to the right hemisphere, is not involved in top-down selection. Instead, this system is specialized for the detection of behaviourally relevant stimuli, particularly when they are salient or unexpected. This ventral frontoparietal network works as a 'circuit breaker' for the dorsal system, directing attention to salient events. Both attentional systems interact during normal vision, and both are disrupted in unilateral spatial neglect.

Control of goal-directed and stimulus-driven attention in the brain

https://surfer.nmr.mgh.harvard.edu/ftp/articles/desikan06-parcellation.pdf

An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest.

https://surfer.nmr.mgh.harvard.edu/ftp/articles/dale99-recon1.pdf

Cortical surface-based analysis. I. Segmentation and surface reconstruction

Co-Planar Stereotaxic Atlas of the Human Brain—3-Dimensional Proportional System: An Approach to Cerebral Imaging, J. Talairach, P. Tournoux. Georg Thieme Verlag, New York (1988), 122 pp., 130 figs. DM 268

fMRI of stereopsis in humans and awake behaving monkeys

Response to Tyler: Representation of stereoscopic structure in human and monkey cortex

Enhanced fMRI using iron oxide contrast agent in awake, behaving primates

Typically, people maintain a certain distance from others ("personal space") during daily life, in a largely automatic, unconscious manner. However during the COVID-19 pandemic, social distancing recommendations led to deliberate expansions of personal space outside of intimate social circles. In the laboratory, personal space preferences are quite stable over repeated measurements. Here, we collected such measurements both before and during the pandemic in the same individuals, using both conventional and virtual reality-based techniques. We found that the size of personal space, and discomfort ratings in response to personal space intrusions, increased significantly during the COVID-19 pandemic, in response to both real humans and virtual "others". Moreover, this increase in personal space requirements correlated with the perceived, not the actual, risk of being infected with COVID-19 - even in a virtual reality environment in which there was no possibility of infection. Thus, quantification of personal space may reveal some of the psychological effects of the pandemic, and subsequent progress towards recovery.

/pdf/personal-space-increases-during-the-covid-19-pandemic-in-3dwg7id56d.pdf

Roger B. H. Tootell

Papers

fMRI of stereopsis in humans and awake behaving monkeys

Response to Tyler: Representation of stereoscopic structure in human and monkey cortex

Enhanced fMRI using iron oxide contrast agent in awake, behaving primates

Personal space Increases during the COVID-19 Pandemic in Response to Real and Virtual Humans

Point-image fMRI experiments in awake behaving macaques