R
Roger M. Perlmutter
Researcher at University of Washington
Publications - 81
Citations - 10244
Roger M. Perlmutter is an academic researcher from University of Washington. The author has contributed to research in topics: T-cell receptor & T cell. The author has an hindex of 47, co-authored 80 publications receiving 10125 citations. Previous affiliations of Roger M. Perlmutter include Merck & Co. & Howard Hughes Medical Institute.
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Journal ArticleDOI
A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27Kip1-Deficient Mice
Matthew L. Fero,Michael J. Rivkin,Michael Tasch,Peggy L. Porter,Catherine E. Carow,Eduardo Firpo,Kornelia Polyak,Li-Huei Tsai,Virginia C. Broudy,Roger M. Perlmutter,Kenneth Kaushansky,James M. Roberts +11 more
TL;DR: P27 deficiency may cause a cell-autonomous defect resulting in enhanced proliferation in response to mitogens, and in the spleen, the absence of p27 selectively enhanced proliferation of hematopoietic progenitor cells.
Journal ArticleDOI
Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs
Julia M. Turner,Michael H. Brodsky,Bryan Irving,Steven D. Levin,Roger M. Perlmutter,Dan R. Littman +5 more
TL;DR: The results suggest a novel role for cysteine-mediated interactions between unrelated proteins and provide a model for the association of other src-like cytoplasmic kinases with transmembrane proteins.
Journal ArticleDOI
Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn
Mark W. Appleby,Jane A. Gross,Michael P. Cooke,Steven D. Levin,Xuan Qian,Roger M. Perlmutter +5 more
TL;DR: Data confirm that p59fynT plays a pivotal role in TCR signal transduction and demonstrate that additional developmentally regulated signaling components also contribute to TCR-induced lymphocyte activation.
Journal ArticleDOI
A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA
Jamey D. Marth,Richard Peet,Richard Peet,Edwin G. Krebs,Roger M. Perlmutter,Roger M. Perlmutter +5 more
TL;DR: It is inferred that the lskT-encoded protein-tyrosine kinase may aid in transducing proliferative or differentiative signals unique to lymphocytes in order to mediate neoplastic transformation in lymphocytes.
Journal ArticleDOI
Selective requirement for MAP kinase activation in thymocyte differentiation.
Jose Alberola-lla,Jose Alberola-lla,Katherine A. Forbush,Katherine A. Forbush,Rony Seger,Rony Seger,Edwin G. Krebs,Roger M. Perlmutter +7 more
TL;DR: The results indicate that the intracellular signals regulating lineage commitment in T cells parallel those in photo-receptor cell specification in Drosophila and vulval cell differentiation in Caenorhabditis elegans suggesting that general rules for cell-type specification could apply among all metazoans.