M
Matthew L. Fero
Researcher at Fred Hutchinson Cancer Research Center
Publications - 37
Citations - 6521
Matthew L. Fero is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Cyclin-dependent kinase & Cellular differentiation. The author has an hindex of 24, co-authored 37 publications receiving 6298 citations. Previous affiliations of Matthew L. Fero include Seattle Cancer Care Alliance & University of California, San Francisco.
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Journal ArticleDOI
A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27Kip1-Deficient Mice
Matthew L. Fero,Michael J. Rivkin,Michael Tasch,Peggy L. Porter,Catherine E. Carow,Eduardo Firpo,Kornelia Polyak,Li-Huei Tsai,Virginia C. Broudy,Roger M. Perlmutter,Kenneth Kaushansky,James M. Roberts +11 more
TL;DR: P27 deficiency may cause a cell-autonomous defect resulting in enhanced proliferation in response to mitogens, and in the spleen, the absence of p27 selectively enhanced proliferation of hematopoietic progenitor cells.
Journal ArticleDOI
The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts.
Mangeng Cheng,Paul Olivier,Paul Olivier,J. Alan Diehl,J. Alan Diehl,Matthew L. Fero,Matthew L. Fero,Martine F. Roussel,James M. Roberts,James M. Roberts,Charles J. Sherr,Charles J. Sherr +11 more
TL;DR: In the absence of both CKIs, the severe reduction in cyclin D‐dependent kinase activity was well tolerated and had no overt effects on the cell cycle.
Journal ArticleDOI
The murine gene p27Kip1 is haplo-insufficient for tumour suppression
Matthew L. Fero,Erin Randel,Kay E. Gurley,James M. Roberts,James M. Roberts,Christopher J. Kemp +5 more
TL;DR: It is shown that both p27 nullizygous and p27 heterozygous mice are predisposed to tumours in multiple tissues when challenged with γ-irradiation or a chemical carcinogen, therefore p27 is a multiple-tissue tumour suppressor in mice.
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Comparative analysis of risk factors for acute graft-versus-host disease and for chronic graft-versus-host disease according to National Institutes of Health consensus criteria
Mary E.D. Flowers,Yoshihiro Inamoto,Paul A. Carpenter,Stephanie J. Lee,Hans-Peter Kiem,Effie W. Petersdorf,Shalini E. Pereira,Richard A. Nash,Marco Mielcarek,Matthew L. Fero,Edus H. Warren,Jean E. Sanders,Rainer Storb,Frederick R. Appelbaum,Barry E. Storer,Barry E. Storer,Paul J. Martin +16 more
TL;DR: The results suggest that the mechanisms involved in acute and chronic GVHD are not entirely congruent and that chronicGVHD is not simply the end stage of acute GV HD.
Journal ArticleDOI
Gene disruption of p27(Kip1) allows cell proliferation in the postnatal and adult organ of corti.
Hubert Löwenheim,David N. Furness,Jonathan Kil,Christoph Zinn,Karina Gültig,Matthew L. Fero,Deanna Frost,Anthony W. Gummer,James M. Roberts,Edwin W. Rubel,Carole M. Hackney,Hans-Peter Zenner +11 more
TL;DR: It is reported that the cyclin-dependent kinase inhibitor p27(Kip1) is selectively expressed in the supporting-cell population of the organ of Corti, and may provide an important pathway for inducing hair-cell regeneration in the mammalian hearing organ.