R
Roger S. Flugel
Researcher at Harvard University
Publications - 13
Citations - 1234
Roger S. Flugel is an academic researcher from Harvard University. The author has contributed to research in topics: Solifenacin & Overactive bladder. The author has an hindex of 7, co-authored 13 publications receiving 1182 citations. Previous affiliations of Roger S. Flugel include Massachusetts Institute of Technology.
Papers
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Journal ArticleDOI
A new enzyme superfamily — the phosphopantetheinyl transferases
Ralph H. Lambalot,Amy M. Gehring,Roger S. Flugel,Peter Zuber,Michael LaCelle,Mohamed A. Marahiel,Ralph Reid,Chaitan Khosla,Christopher T. Walsh +8 more
TL;DR: This work has identified a large family of proteins having 12-22 % similarity with ACPS, which are putative P-pant transferases, and found three of these proteins, E. coli EntD and o195, and subtilis Sfp, have been overproduced, purified and found to have P- pant transferase activity.
Journal ArticleDOI
Post-translational modification of polyketide and nonribosomal peptide synthases.
TL;DR: Phosphopantetheinyl transferases required for fatty acid, peptide and siderophore biosynthesis have been characterized and a consensus sequence noted in order to facilitate future identification of additional proteins catalyzing phosphopantethinyl transfer.
Journal ArticleDOI
Holo-(acyl carrier protein) synthase and phosphopantetheinyl transfer in Escherichia coli.
TL;DR: It is shown that a conditional acpS mutant accumulates apoACPin vivo under nonpermissive conditions in a manner similar to the E. coli MP4 strain, and it is demonstrated that the gene product, YhhU, of a previously identified E. Escherichia coli open reading frame can completely suppress theacpS conditional, lethal phenotype upon overexpression of the protein.
Journal ArticleDOI
Melting of phospholipid tubules.
George Nounesis,Banahalli R. Ratna,Sung-Tae Shin,Roger S. Flugel,Samuel Sprunt,Alok Singh,J. D. Litster,Ranganathan Shashidhar,Satyendra Kumar +8 more
TL;DR: The melting of lipid-based microcylinders (tubules) has been investigated for systems with single and multiple bilayer walls using high field, magnetic birefringence, and precision microcalorimetry.
Patent
Methods of improving quality of sleep
Mehdi Paborji,Roger S. Flugel +1 more
TL;DR: In this paper, a combination of antimuscarinic or anticholinergic agent and muscarinic agonist for the treatment of poor quality of sleep in the OAB patient was presented.