Showing papers by "Roger White published in 2003"
TL;DR: The goal is to identify the key nuclear receptor(s) and their target genes responsible for ovulation and to demonstrate the importance of RIP140 in female fertility and in adipose biology.
15 citations
Patent•
04 Jul 2003TL;DR: In this article, screening methods for identifying compounds that are useful as contraceptives are provided, in particular, the compounds inhibit the interaction between steroidogenic factor 1 (SF-1) and nuclear receptor interacting protein (Nrip1) or up-regulate SF-1 expression.
Abstract: Screening methods for identifying compounds that are useful as contraceptives are provided. In particular, the compounds inhibit the interaction between steroidogenic factor 1 (SF-1) and nuclear receptor interacting protein (Nrip1) or the up-regulate SF-1 expression.
1 citations
01 Jan 2003
TL;DR: The goal is to identify the key nuclear receptor(s) and their target genes responsible for ovulation and to demonstrate that mice devoid of RIP140 indicate that it plays a crucial role in female fertility and in adipose biology.
Abstract: Nuclear receptors function as ligand-dependent tran- scription factors by recruiting cofactors that remodel chromatin and recruit the transcription machinery. RIP140 (receptor in- teracting protein with a molecular weight of 140 kDa) is a widely expressed corepressor that has the potential to inhibit the transcriptional activity of most, if not all nuclear receptors. Mice devoid of RIP140 indicate that it plays a crucial role in female fertility and in adipose biology. It is essential in the ovary for ovulation, speci¢cally oocyte release but not luteinisa- tion of mature follicles. Our goal is to identify the key nuclear receptor(s) and their target genes responsible for ovulation. ) 2003 Federation of European Biochemical Societies. Pub- lished by Elsevier Science B.V. All rights reserved.