Stuart Milligan

TL;DR: The maintenance of energy homeostasis requires the action of a transcriptional repressor in white adipose tissue, and ligand-dependent recruitment of RIP140 to nuclear receptors may provide a therapeutic target in the treatment of obesity and related disorders.

TL;DR: Results indicate that the endocrine properties of female flowers of the hop plant, including 8-prenyl-naringenin, do not have progestogenic or androgenic properties.

TL;DR: It is shown that the co-repressor nuclear-receptor-interacting protein 1 (Nrip1; encoded by the gene Nrip1) is essential for ovulation, and that the ability to suppress the action of nuclear receptors isessential for the coordinated control of ovarian function with the essential process of oocyte release dependent on the activity of the transcriptional co- Repressor Nrip 1 (RIP40).

TL;DR: The oestrogenic activity of 8-prenyl-naringenin in vitro was greater than that of established phyto-oestrogens such as coumestrol, genistein and daidzein and was confirmed in an acute in vivo test using uterine vascular permeability as an end point.

TL;DR: These data are the first to identify the arcuate nucleus as a key site for kisspeptin modulation of LH pulse frequency, supporting the notion thatkisspeptin-GPR54 signalling in this region of the mediobasal hypothalamus is a critical neural component of the hypothalamic GnRH pulse generator.