R
Roland A. Cooper
Researcher at National Institutes of Health
Publications - 15
Citations - 2843
Roland A. Cooper is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Plasmodium falciparum & Medicine. The author has an hindex of 8, co-authored 9 publications receiving 2708 citations. Previous affiliations of Roland A. Cooper include University of Notre Dame & Old Dominion University.
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Journal ArticleDOI
Mutations in the P. falciparum Digestive Vacuole Transmembrane Protein PfCRT and Evidence for Their Role in Chloroquine Resistance
David A. Fidock,Takashi Nomura,Angela K. Talley,Roland A. Cooper,Sergey M. Dzekunov,Michael T. Ferdig,Lyann M. B. Ursos,Amar Bir Singh Sidhu,Bronwen Naudé,Kirk W. Deitsch,Xin-zhuan Su,John C. Wootton,Paul D. Roepe,Thomas E. Wellems +13 more
TL;DR: The determinant of verapamil-reversible chloroquine resistance (CQR) in a Plasmodium falciparum genetic cross maps to a 36 kb segment of chromosome 7 that harbors a 13-exon gene, pfcrt, having point mutations that associate completely with CQR in parasite lines from Asia, Africa, and South America.
Journal ArticleDOI
Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum
John C. Wootton,Xiaorong Feng,Michael T. Ferdig,Roland A. Cooper,Jianbing Mu,Dror I. Baruch,Alan J. Magill,Alan J. Magill,Xin-zhuan Su +8 more
TL;DR: The presence of linkage disequilibrium provides a basis for mapping genes under drug selection in P. falciparum, and its decay rate in the pfcrt-flanking region are consistent with strong directional selective sweeps occurring over ∼20–80 sexual generations.
Journal ArticleDOI
Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum.
Roland A. Cooper,Michael T. Ferdig,Xin-zhuan Su,Lyann M. B. Ursos,Jianbing Mu,Takashi Nomura,Hisashi Fujioka,David A. Fidock,Paul D. Roepe,Thomas E. Wellems +9 more
TL;DR: It is concluded that the K76N or K76I change added to the other pre-existing mutations in the 106/1 PfCRT protein was responsible for CQR.
Journal ArticleDOI
Dissecting the loci of low‐level quinine resistance in malaria parasites
Michael T. Ferdig,Roland A. Cooper,Roland A. Cooper,Roland A. Cooper,Jianbing Mu,Bingbing Deng,Deirdre A. Joy,Xin-zhuan Su,Thomas E. Wellems +8 more
TL;DR: Results identify additive QTL in segments of chromosomes (Chrs) 13, 7 and 5, and pairwise effects from two additional loci of Chrs 9 and 6 that interact, respectively, with the QTL of ChRS 13 and 7.
Journal ArticleDOI
Allelic modifications of the cg2 and cg1 genes do not alter the chloroquine response of drug-resistant Plasmodium falciparum.
David A. Fidock,Takashi Nomura,Roland A. Cooper,Xin-zhuan Su,Angela K. Talley,Thomas E. Wellems +5 more
TL;DR: In this article, the determinant of chloroquine resistance (CQR) in a Plasmodium falciparum cross was mapped by linkage analysis to a 36 kb segment of chromosome 7.