P
Paul D. Roepe
Researcher at University of Washington
Publications - 20
Citations - 2240
Paul D. Roepe is an academic researcher from University of Washington. The author has contributed to research in topics: Plasmodium falciparum & Chloroquine. The author has an hindex of 12, co-authored 20 publications receiving 2060 citations.
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Journal ArticleDOI
Mutations in the P. falciparum Digestive Vacuole Transmembrane Protein PfCRT and Evidence for Their Role in Chloroquine Resistance
David A. Fidock,Takashi Nomura,Angela K. Talley,Roland A. Cooper,Sergey M. Dzekunov,Michael T. Ferdig,Lyann M. B. Ursos,Amar Bir Singh Sidhu,Bronwen Naudé,Kirk W. Deitsch,Xin-zhuan Su,John C. Wootton,Paul D. Roepe,Thomas E. Wellems +13 more
TL;DR: The determinant of verapamil-reversible chloroquine resistance (CQR) in a Plasmodium falciparum genetic cross maps to a 36 kb segment of chromosome 7 that harbors a 13-exon gene, pfcrt, having point mutations that associate completely with CQR in parasite lines from Asia, Africa, and South America.
Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea
Rajeev K. Mehlotra,Hisashi Fujioka,Paul D. Roepe,Omar Janneh,Lyann M. B. Ursos,Vanessa Jacobs-Lorena,David T. McNamara,Moses J. Bockarie,James W. Kazura,Dennis E. Kyle,David A. Fidock,Peter A. Zimmerman +11 more
TL;DR: In this article, the authors investigated the mechanistic basis for chloroquine resistance (CQR) in Plasmodium falciparum recently has been linked to the polymorphic gene pfcrt.
Journal ArticleDOI
Chloroquine resistance modulated in vitro by expression levels of the Plasmodium falciparum chloroquine resistance transporter.
Karena L. Waller,Rebecca A. Muhle,Lyann M. B. Ursos,Paul Horrocks,Dominik Verdier-Pinard,Amar Bir Singh Sidhu,Hisashi Fujioka,Paul D. Roepe,David A. Fidock +8 more
TL;DR: Genetic truncation of 3′-untranslated regions provides a useful approach for assessing the impact of candidate genes on drug resistance or other quantifiable phenotypes in P. falciparum.
Journal ArticleDOI
Structure and drug resistance of the Plasmodium falciparum transporter PfCRT
Jonathan Kim,Yong Zi Tan,Kathryn J. Wicht,Satchal K. Erramilli,Satish K. Dhingra,John Okombo,Jeremie Vendome,Laura M. Hagenah,Sabrina I. Giacometti,Audrey L. Warren,Kamil Nosol,Paul D. Roepe,Clinton S. Potter,Bridget Carragher,Anthony A. Kossiakoff,Matthias Quick,David A. Fidock,Filippo Mancia +17 more
TL;DR: Structural, functional and in silico analyses of the chloroquine-resistance transporter PfCRT of Plasmodium falciparum suggest that distinct mechanistic features mediate the resistance to chloroquines and piperaquine in drug-resistant parasites.
Journal ArticleDOI
Analysis of the antimalarial drug resistance protein Pfcrt expressed in yeast.
TL;DR: This is the first successful expression of a full-length malarial parasite integral membrane protein in yeast and expands on the role of Pfcrt in conferring CQR and defines a productive route for analysis of important P. falciparum transport proteins and membrane associated vaccine candidates.