R
Roland Kath
Researcher at Wistar Institute
Publications - 7
Citations - 477
Roland Kath is an academic researcher from Wistar Institute. The author has contributed to research in topics: Growth factor & Melanoma. The author has an hindex of 6, co-authored 7 publications receiving 472 citations.
Papers
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Journal ArticleDOI
Constitutive Expression of Multiple Growth Factor Genes by Melanoma Cells but Not Normal Melanocytes
Ulrich Rodeck,Karl Melber,Roland Kath,Hans-Dietrich Menssen,Michael A. Varello,Barbara Atkinson,Meenhard Herlyn +6 more
TL;DR: The results indicate that multiple growth factors are expressed simultaneously and constitutively by melanoma cells but not normal melanocytes in culture, suggesting that bioactive TGF- beta may represent a physiologic growth inhibitor.
Book ChapterDOI
Growth-regulatory factors for normal, premalignant, and malignant human cells in vitro.
TL;DR: In addition to the use of anti-growth factor antibodies, other strategies for the inhibition of autocrine growth stimulation include mAbs to growth factor receptors, soluble receptors, receptor-mimicking antiidiotype antibodies, and active immunization against growth factors.
Journal Article
Characterization of Tenascin Secreted by Human Melanoma Cells
Meenhard Herlyn,Ullrich Graeven,David W. Speicher,Ben-Ami Sela,Jeannette L. Bennicelli,Roland Kath,DuPont Guerry +6 more
TL;DR: Results indicate that tenascin may play a critical role in cell-substrate interactions of melanoma cells, with significantly elevated levels in patients with advanced melanomas as compared to patients with low tumor burden or to normal donors.
Journal Article
Development of Invasive and Growth Factor-independent Cell Variants from Primary Human Melanomas
TL;DR: The results indicate that primary melanoma cells contain subpopulations of cells that have the phenotype of an advanced (metastatic) stage of tumor progression, but this phenotype is not stable without selective pressure.
Journal Article
Tumor progression in the human melanocytic system.
Roland Kath,Ulrich Rodeck,Hans D. Menssen,Maria Laura Mancianti,Alban Linnenbach,David E. Elder,Meenhard Herlyn +6 more
TL;DR: The availability of cells from sequential steps of tumor progression in the human melanocytic system offers a unique experimental model for the study of malignant transformation.