Showing papers in "Journal of Investigative Dermatology in 1991"

TL;DR: Findings suggest that an insufficiency of ceramides in the stratum corneum is an etiologic factor in atopic dry skin.

TL;DR: The structure of human stratum corneum was investigated with small-angle X-ray scattering (SAXS) and it is concluded that in the original curve the lipids are arranged in two unit cells with repeat distances of 6.4 nm and 13.

TL;DR: Psoriasin was not detected in normal human fibroblasts, lymphocytes, endothelial cells and transformed epithelial cells of keratinocyte origin, suggesting that its overexpression by psoriatic keratinocytes may be linked to the inflammatory stimuli.

TL;DR: A functional consequence of these cytokine profiles was demonstrated by the finding that TLC producing substantial amounts of IL-4 enhanced expression of the low-affinity Fc receptor for IgE (CD23) on antigen-presenting cells to a greater extent than did IFN-gamma-producing TLC.

TL;DR: The heterogeneity of the disease patterns in mastocytosis strongly suggests that more than one biologic lesion may occur in the developmental sequence that leads to placement of mature mast cells in tissues.

TL;DR: The permeability (P) and lag-time (Tlag) for water vapor transport through the SC is found to be about 1000 times less than the values obtained for most other lipid membranes, and the intrinsic diffusion of water is comparable to values obtained withother lipid membranes.

TL;DR: It is found that only active (Dopa-positive) melanocytes existed in the epidermis of normal skin, and the existence of these inactive melanocytes provided the melanocyte sources for repigmentation of vitiligo.

TL;DR: A new hypothesis has been formulated for the pathogenesis of vitiligo based on a consistent reduction in levels of catalase compared to normal healthy controls of matched photo-skin types and a increase in the concentration of hydrogen peroxide in the epidermis of these patients.

TL;DR: Results suggest that IL-6 could function as a paracrine/autocrine regulator of dermal fibrotic repair in connective tissue-related biosynthetic functions of three lines of cultured human adult der mal fibroblasts.

TL;DR: The new RuO4 protocol provides quantitative information about SC lamellar dimensions and morphologic abnormalities in bilayer distribution and substructure in EFAD stratum corneum that are not detected by either x-ray diffraction or computer-aided image reconstruction.

TL;DR: The present findings could be particularly significant in view of recent suggestions that pheomelanin, rather than protecting the skin against UV radiation, may actually contribute to UV-induced skin damage.

TL;DR: Human recombinant tissue inhibitor of metalloproteinases (rTIMP) was found to stimulate the growth of normal human keratinocytes, in primary cultures on a plastic support, and to markedly increase their growth on a tridimensional culture system, the skin equivalent, as shown by histology, DNA measurements, and planimetry.

TL;DR: It is suggested that the mechanical activity of fibroblasts and the control of the tension that they operate on the lattice support participate in the structural organization of the dermis and in its physiologic tension.

TL;DR: The results indicate that cells in the basal layer, while their DNA is perfectly intact, are preparing to die and DNA fragmentation is initiated in the granular keratinocyte layer and is identical in pattern to that seen in other examples of programmed cell death.

TL;DR: The initial step in the development of fibrotic reaction in keloids involves the expression of the TGF-beta 1 gene by the neovascular endothelial cells, thus activating the adjacent fibroblasts to express markedly elevated levels of TGF -beta 1, as well as type I and VI collagen genes.

TL;DR: In these biopsies, the inflammation induced in response to PPD differed from UV-B-induced inflammation in showing prolonged expression of endothelial ELAM-1, induction of VCam-1 on endothelium and other cells, and induction of keratinocyte ICAM- 1.

TL;DR: It is concluded that low oxygen tension upregulates the synthesis of TGF-β1 by human dermal fibroblasts, and leads to increased secretion of this peptide.

TL;DR: This is the first demonstration that NHM respond to epidermal cytokines, and suggests a role for paracrine and possibly autocrine regulation of melanocytes by immune modulators.

TL;DR: Results demonstrate constitutive expression of RAR-gamma in human epidermis, and suggest that RAR -gamma is a molecular target of RA action in adult human skin.

TL;DR: It is concluded that DM-EBS is associated with an intrinsic abnormality of the keratin-filament network involving the K5 and K14 pair that is likely to result in impaired resistance of basal epidermal cells to external shearing forces, leading to the characteristic intraepidermal blisters.

TL;DR: The physial alteration of pigment granules, redistribution, and elimination appear to account for clinical lightening of the tattoos, confirming that short-pulse radiation can be used to selectively disrupt cells containing tattoo pigments.

TL;DR: Findings indicate that increased IL-6 production by EC after UVB irradiation may mediate local and systemic inflammatory reactions following extensive sun exposure, and the therapeutic effect of corticosteroids observed in various inflammatory diseases may be partly due to their downregulating capacity of IL- 6 production.

TL;DR: Although lipid is a component of the water permeability barrier in both skin and oral mucosa, different lipid components subserve this function in keratinized and non-keratinized tissues.

TL;DR: The results indicate that multiple growth factors are expressed simultaneously and constitutively by melanoma cells but not normal melanocytes in culture, suggesting that bioactive TGF- beta may represent a physiologic growth inhibitor.

TL;DR: In this article, the retinoid reaction in non-sun-exposed skin with 0.1% retinoic acid cream (Retin-A, Ortho Pharmaceutical Corporation, Raritan, NJ) under occlusion for 4 d to induce erythema was investigated.

TL;DR: Investigations indicate that 13-cis-RA and, to a lesser extent, all-trans-RA are potent inhibitors of both cell proliferation and lipid synthesis in human sebocytes in vitro, whereas acitretin only decreases lipogenesis in this model.

TL;DR: The notion that IL-8, rather than IL-6, is an important disease-promoting cytokine in PS is supported and local pharmacologic down-regulation of NAP-1/IL-8 activity could be a promising therapeutic strategy in PS.

TL;DR: Findings indicate that a correlation exists between the incidence and level of pigment cell antibodies and the activity of vitiligo, and support the hypothesis that vitILigo is an autoimmune disease mediated by an immune reaction to pigment cells.

TL;DR: Cutaneous and gastrointestinal symptoms and findings were the most prominent chronic manifestations; episodic vascular collapse was the most dramatic acute event.

TL;DR: Late differentiation antigens (Ag) specific for human cornified squamous epithelia, defined by two murine monoclonal antibodies, G36-19 and B17-21, produced after immunization with plantar stratum corneum (SC), are described and are relevant markers for studying desmosomal maturation during epidermal differentiation and desquamation.