R
Roland O. John
Researcher at University of Vienna
Publications - 8
Citations - 572
Roland O. John is an academic researcher from University of Vienna. The author has contributed to research in topics: Ruthenium & Maltol. The author has an hindex of 8, co-authored 8 publications receiving 528 citations. Previous affiliations of Roland O. John include Max Planck Society & Vienna University of Technology.
Papers
More filters
Journal ArticleDOI
Highly Antiproliferative Ruthenium(II) and Osmium(II) Arene Complexes with Paullone-Derived Ligands
TL;DR: The IC50 values indicate the paullones' high antiproliferative activity in all three cell lines, making them potential candidates for further development as antitumor drugs.
Journal ArticleDOI
In vitro anticancer activity and biologically relevant metabolization of organometallic ruthenium complexes with carbohydrate-based ligands.
Isabella Berger,Muhammad Hanif,Alexey A. Nazarov,Alexey A. Nazarov,Christian G. Hartinger,Christian G. Hartinger,Roland O. John,Maxim L. Kuznetsov,Michael Groessl,Frédéric Schmitt,Olivier Zava,Florian Biba,Vladimir B. Arion,Markus Galanski,Michael A. Jakupec,Lucienne Juillerat-Jeanneret,Paul J. Dyson,Bernhard K. Keppler +17 more
TL;DR: In vitro studies revealed that the 3,5,6-bicyclophosphite-1,2-O-cyclohexylidene-alpha-D-glucofuranoside complex is the most cytotoxic compound in human cancer cell lines (IC50 values from 30 to 300 microM depending on the cell line).
Journal ArticleDOI
From Pyrone to Thiopyrone Ligands−Rendering Maltol-Derived Ruthenium(II)−Arene Complexes That Are Anticancer Active in Vitro
Wolfgang Kandioller,Christian G. Hartinger,Alexey A. Nazarov,Alexey A. Nazarov,Maxim L. Kuznetsov,Roland O. John,Caroline Bartel,Michael A. Jakupec,Vladimir B. Arion,Bernhard K. Keppler +9 more
TL;DR: Ru(II)-arene complexes with pyrone-derived ligands are rendered active against cancer cells by replacement of the coordinated O,O donor with an S, O donor.
Journal ArticleDOI
Water-Soluble Mixed-Ligand Ruthenium(II) and Osmium(II) Arene Complexes with High Antiproliferative Activity
TL;DR: The synthesis of ruthenium(II) and osmium (II) arene complexes of the general formula (η6p-cymene)M(oxine)(Hazole)X, where M = Ru, Os; oxine = deprotonated 8-hydroxyquinoline, and Hazole = azole.
Journal ArticleDOI
Tuning the anticancer activity of maltol-derived ruthenium complexes by derivatization of the 3-hydroxy-4-pyrone moiety
Wolfgang Kandioller,Christian G. Hartinger,Christian G. Hartinger,Alexey A. Nazarov,Alexey A. Nazarov,Johanna Kasser,Roland O. John,Michael A. Jakupec,Vladimir B. Arion,Paul J. Dyson,Bernhard K. Keppler +10 more
TL;DR: Aldol reaction of allomaltol with arom aldehydes, eg, RC6H4CHO, R = H, 4NO2, 4-F, 2-F and 3,4,5-(MeO)3C5H2CHO, gave 2-(hydroxyphenylmethyl)-3-hydroxy-6-methylpyran-4(1)-ones, maltol-derived ligands Organometallic Ru(II)-arene complexes, [RuCl2(cymene)]2, coordinated to the maltol