R
Roland Rosqvist
Researcher at Umeå University
Publications - 47
Citations - 6574
Roland Rosqvist is an academic researcher from Umeå University. The author has contributed to research in topics: Yersinia pseudotuberculosis & Yersinia. The author has an hindex of 31, co-authored 47 publications receiving 6458 citations.
Papers
More filters
Journal ArticleDOI
Target cell contact triggers expression and polarized transfer of Yersinia YopE cytotoxin into mammalian cells.
TL;DR: The results suggest that the pathogen senses cell structures and focuses the transfer of YopE to occur solely at the interaction zone between the bacterium and the eukaryotic cell.
Journal ArticleDOI
The YopB protein of Yersinia pseudotuberculosis is essential for the translocation of Yop effector proteins across the target cell plasma membrane and displays a contact-dependent membrane disrupting activity
Sebastian Håkansson,Kurt Schesser,Cathrine Persson,Edouard E. Galyov,Roland Rosqvist,Fabrice Homblé,Hans Wolf-Watz +6 more
TL;DR: It is proposed that YopB is essential for the formation of a pore in the target cell membrane that is required for the cell‐to‐cell transfer of Yop effector proteins.
Journal ArticleDOI
Intracellular targeting of the Yersinia YopE cytotoxin in mammalian cells induces actin microfilament disruption.
TL;DR: It is shown that isolated Yop proteins indeed can cause cytotoxic effects in vitro if the proteins are introduced intracellularly into the eukaryotic cell, and the requirement for at least some of the Yopprotein to leave the pathogen during infection is elucidated.
Journal ArticleDOI
The cytotoxic protein YopE of Yersinia obstructs the primary host defence.
TL;DR: A role is proposed for YopE in the virulence process of Yersinia where it influences the ability of the pathogen to resist phagocytosis and induces a cytotoxic response on mouse macrophages.
Journal ArticleDOI
GAP activity of the Yersinia YopE cytotoxin specifically targets the Rho pathway: a mechanism for disruption of actin microfilament structure.
Ulrich von Pawel-Rammingen,Maxim V. Telepnev,Gudula Schmidt,Klaus Aktories,Hans Wolf-Watz,Roland Rosqvist +5 more
TL;DR: Evidence is provided that YopE exhibits a GAP activity to inactivate RhoGTPases, leading to depolymerization of the actin stress fibres in eukaryotic cells and growth inhibition in yeast.