Microparticles formed by mixing a macromolecule with a polymer at a pH near the isoelectric point of the macromolecule and incubating the mixture in the presence of an energy source for a predetermined length of time. The microparticles are composed of homogeneously distributed, intertwined macromolecule and polymer. Each microparticle allows aqueous fluids to enter and allows solubilized macromolecule and polymer to exit the microparticle and may be formulated to provide a sustained release of macromolecule and polymer from the interior of the microparticle when placed in an appropriate aqueous medium, such as under physiological conditions. Methods of production and methods of use for research, diagnostics and therapeutics are provided.

Macromolecular microparticles and methods of production and use

This invention is directed to an m x n array of different chemical compounds wherein each of said compounds has at least one structural diversity element selected from a group of amines and ketones and wherein the scaffold structure is selected from a group consisting of aminimide, imidazolone, sulfonylaminimide and phosphonylaminimide.

A method of generating a plurality of chemical compounds in a spatially arranged array

A modified polysaccharide material which comprises: (1) polysaccharide covalently bonded to a synthetic polymer; (2) the synthetic polymer being made from (a) a polymerizable compound which is capable of being covalently coupled directly or indirectly to said polysaccharide, and (b) one or more polymerizable compounds containing (i) an ionizable chemcial group, (ii) a chemical group capable of transformation to an ionizable chemical group, (iii) a chemical group capable of causing the covalent coupling of the compound (b) to an affinity ligand or a biologically active molecule or (iv) a hydrophobic compound.

Modified polysaccharide supports

Carriers coated with a copolymer of a hydrophilic acrylate or methacrylate monomer and a copolymerizable unsaturated carboxylic acid or unsaturated amine are provided which are substantially free from nonspecific adsorption of proteins and the like. Due to the side-chain carboxyl or amino groups of the copolymer, these coated carriers are able to immobilize bio-active materials such as antigens, antibodies, complements and enzymes. These carriers, on which bio-active materials can be immobilized, are useful as clinical selective adsorbents, affinity-chromatographic adsorbents, selective electrodes or columns for analysis.

Carrier having acrylate copolymer coating for immobilization of bioactive materials

An active agent containing controlled release diffusion device comprising a swellable hydrogel matrix in the non-swollen state, interpenetrated with an active agent solute having a stable concentration distribution increasing in a gradient normal to the surface of the device and between the surface and the core thereof, said gradient being in the form of a substantially continuous, inflection point containing, sigmoidal curve, such that the device, when placed in an aqueous hydrogel swelling environment, releases said active agent in a controlled continuous manner by diffusion for a predetermined period of time, a method of preparing such a device, and the use thereof to release an active agent into the intended environment of use.

Active agent containing hydrogel devices wherein the active agent concentration profile contains a sigmoidal concentration gradient for improved constant release, their manufacture and use

Water-swellable, cross-linked, bead copolymers of (A) an ethylenically unsaturated monomer having a carboxylic acid anhydride, glycidyl or succinimide group, (B) a comonomer having at least two radical-polymerizable carbon double bonds, and (C) a radical-polymerizable water-soluble comonomer are disclosed to be excellent carriers capable of bonding with biologically active substances such as enzymes, enzyme substrates, inhibitors, hormones, antibiotics, antigens, and peptides.

Water-swellable, bead copolymer

What are disclosed are concentrated emulsions of an olefin copolymer in a liquid carrier medium which does not dissolve the copolymer and, as an emulsifier, a graft or block copolymer of the formula A--Y, wherein A represents a sequence or segment of an olefin copolymer, of hydrogenated polyisoprene, or of an hydrogenated butadiene/isoprene copolymer, and Y represents a sequence or segment, formed by the polymerization of vinyl monomers which essentially are not of the acrylate or methacrylate type, which is soluble in the carrier medium, as well as methods for making the same.

Concentrated emulsions of olefin copolymers

Die Erfindung betrifft ein Verfahren zur Herstellung von konzentrierten Emulsionen von Olefincopolymerisaten in zur Anwendung in Oladditiven geeigneten Tragermedien, ohne vorausgehendes Auflosen der Olefincopolymerisate, wobei man die Losung eines Emulgators des Typs I
 worin A fur Olefincopolymerisat-Sequenzen, hydrierten Polyisopren-Sequenzen oder hydrierten Copolymeren aus Butadien/Isopren, und X aus Polyacrylat und/oder Polymethacrylat aufgebaute Sequenzen bedeutet, in einem Tragermedium T herstellt, welches die Olefincopolymerisate im wesentlichen nicht lost, die Sequenzen X jedoch lost und im Temperaturbereich zwischen 40 und 150°C unter Anwendung von Scherkraften die Olefincopolymerisate in der Losung des Emulgators im Tragermedium T emulgiert.

Konzentrierte Emulsionen von Olefincopolymerisaten

Die Erfindung betrifft ein Verfahren zur Herstellung von konzentrierten Emulsionen von Olefincopolymerisaten in zur Anwendung in Oladditiven geeigneten Tragermedien, ohne vorausgehendes Auflosen der Olefincopolymerisate, wobei man die Losung eines Emulgators des Typs I The invention relates to a process for preparing concentrated emulsions of olefin copolymers for use in oil additives in suitable carrier media without preliminarily dissolve the olefin copolymers, wherein one I, the solution of an emulsifier of the type worin A fur Olefincopolymerisat-Sequenzen, hydrierten Polyisopren-Sequenzen oder hydrierten Copolymeren aus Butadien/Isopren, und X aus Polyacrylat und/oder Polymethacrylat aufgebaute Sequenzen bedeutet, in einem Tragermedium T herstellt, welches die Olefincopolymerisate im wesentlichen nicht lost, die Sequenzen X jedoch lost und im Temperaturbereich zwischen 40 und 150°C unter Anwendung von Scherkraften die Olefincopolymerisate in der Losung des Emulgators im Tragermedium T emulgiert. wherein A represents olefin copolymer sequences, hydrogenated polyisoprene sequences or hydrogenated copolymers of butadiene / isoprene, and X is selected from polyacrylate and / or polymethacrylate means constructed sequences prepared in a carrier medium T which does not dissolve the olefin copolymers to substantially dissolve the sequences X but and emulsified in a temperature range between 40 and 150 ° C under the application of shear forces, the olefin copolymers in the solution of the emulsifier in the carrier medium T.

Roland Schweder

Papers

Water-swellable, bead copolymer

Concentrated emulsions of olefin copolymers

Konzentrierte Emulsionen von Olefincopolymerisaten

Concentrated dispersions of olefinic copolymers