R
Rolf E. Brenner
Researcher at University of Ulm
Publications - 163
Citations - 6570
Rolf E. Brenner is an academic researcher from University of Ulm. The author has contributed to research in topics: Mesenchymal stem cell & Osteogenesis imperfecta. The author has an hindex of 38, co-authored 158 publications receiving 6009 citations. Previous affiliations of Rolf E. Brenner include Max Planck Society & University of Bonn.
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Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cells.
Andreas Hermann,Regina Gastl,Stefan Liebau,M. Oana Popa,Jörg Fiedler,Bernhard O. Boehm,Martina Maisel,Holger Lerche,Johannes Schwarz,Johannes Schwarz,Rolf E. Brenner,Alexander Storch +11 more
TL;DR: The efficient conversion of human adult bone marrow stromal cells (hMSC) into a neural stem cell-like population (hmNSC, for human marrow-derived NSC-like cells) is described and it is demonstrated that individual hmNSCs are multipotent and retain the capacity to generate both glia and neurons.
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Vascular endothelial growth factor stimulates chemotactic migration of primary human osteoblasts
U Mayr-Wohlfart,Johannes Waltenberger,H Hausser,S. Kessler,K. P. Günther,Christoph Dehio,Wolfhart Puhl,Rolf E. Brenner +7 more
TL;DR: The data establish that human osteoblasts respond to VEGF-A, suggesting a functional role for this growth factor in bone formation and remodeling.
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BMP-2, BMP-4, and PDGF-bb stimulate chemotactic migration of primary human mesenchymal progenitor cells.
TL;DR: A functional role for recruitment of MPCs during bone development and remodeling, as well as fracture healing is suggested, including the change in response to growth factors after differentiation.
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TNFα promotes osteogenic differentiation of human mesenchymal stem cells by triggering the NF-κB signaling pathway
TL;DR: The results suggest that NF-kappaB activation may function in lineage selection during differentiation of hMSCs by fostering osteogenic differentiation at the expense of other differentiation lineages.
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Identification of subpopulations with characteristics of mesenchymal progenitor cells from human osteoarthritic cartilage using triple staining for cell surface markers.
TL;DR: Human osteoarthritic cartilage contains cells with characteristics of MPCs, and their relative enrichment during in vitro cultivation and the ability of cell sorting to obtain more homogeneous populations offer interesting perspectives for future studies on the activation of regenerative processes within osteOarthritic joints.