Showing papers in "Bone in 2002"

TL;DR: It is suggested that vitamin D deficiency is unlikely in the two seasonal subpopulations of noninstitutionalized adolescents and adults that can be validly assessed in NHANES III and that insufficiency occurred fairly frequently in younger individuals, especially in the winter/lower latitude subsample.

TL;DR: The results indicate that the adverse changes in the collagen network occur as people age and such changes may lead to the decreased toughness of bone and suggest that nonenzymatic glycation may be an important contributing factor causing changes in collagen and, consequently, leading to the age-related deterioration of bone quality.

TL;DR: A number of mechanisms for the fat-bone relationship exist and include the effect of soft tissue mass on skeletal loading, the association of fat mass with the secretion of bone-active hormones from the pancreatic β cell (including insulin, amylin, and preptin), and the boneactive hormones (e.g., estrogens and leptin) from the adipocyte.

TL;DR: It is concluded that application of the techniques investigated here can lead to a better prediction of the bone failure load for bone in vivo than is possible from DXA measurements, structural parameters, or a combination thereof.

TL;DR: Results indicate that IL-6 and IL-11, which are thought to play a role in several osteolytic bone disorders, are directly capable of inducing osteoclast formation by a RANKL-independent mechanism.

TL;DR: In this mini-review, the purposes and instruments of bone remodeling and how they are related are examined.

TL;DR: Experimental evidence suggests that short periods of exercise, with a 4-8 h rest period between them, are a more effective osteogenic stimulus than a single sustained session of exercise.

TL;DR: The data establish that human osteoblasts respond to VEGF-A, suggesting a functional role for this growth factor in bone formation and remodeling.

TL;DR: Questions that remain to be addressed include whether targeted remodeling does in fact occur; how much of bone’s total turnover is targeted and how much is nontargeted (stochastic); and whether these forms of remodeling are independently controlled.

TL;DR: There is evidence that changes in collagen content, or changes to inter- and intrafibrillar collagen cross-linking, can reduce the energy required to cause bone failure (toughness), and increase fracture risk.

TL;DR: Protection of bone in the presence of continued inflammation in arthritic rats treated with osteoprotegerin (OPG) supports the concept that osteoclasts mediate bone loss, providing further evidence that OPG protects bone integrity by downregulating osteoclastogenesis and promoting osteOClast apoptosis.

TL;DR: To the authors' knowledge, this is the first study reported in the literature demonstrating the long-term effect of strong back muscles on the reduction of vertebral fractures in estrogen-deficient women.

TL;DR: The indentation modulus and hardness of bone ECM were investigated as a function of lamella type and indentation depth under wet and dry conditions and support compositional and/or ultrastructural differences between thick and thin lamellae.

TL;DR: Only ERalpha was shown to regulate bone remodeling in males, whereas in females both receptor subtypes influenced this process and could, at least under basal knockout conditions, compensate for each other.

TL;DR: The regression model indicates that there will be about three times more low-trauma ankle fractures in Finland in the year 2030 than there was in 2000, and potentially effective preventive measures, such as prevention of slippings, trippings, and falls in elderly people, and use of ankle supports, should be urgently studied.

TL;DR: This first study of Macrophage BMP-2 expression indicates that the macrophage is capable of physiological regulation consistent with a key role in osteoinduction for osseous wound healing.

TL;DR: It was concluded that the microscale measurement of biological Ap texture is one of the useful new methods for evaluating mechanical function and stress distribution in vivo in calcified tissues.

TL;DR: It is proposed that brief exposure to slight elevations in these endogenous mechanical signals would suffice to increase bone mass in those bones subject to the stimulus, and that a noninvasive stimulus based on this sensitivity has potential for treating skeletal complications such as osteoporosis.

TL;DR: The results suggest that PI 3 kinase, p38, and ERK play roles in osteoclast differentiation, at least in part, by participating in RANKL signaling.

TL;DR: The results of this study demonstrate that samples for sCTx should be taken in the fasting state, and show that Nasal salmon calcitonin, an antiresorptive drug used for treatment of osteoporosis, was not able to break the circadian pattern whether the treatment was administered in the morning or the evening.

TL;DR: The clinical impact of feeding vs. fasting on the concentration and between-day variability of several markers is small with the exception of sbetaCTX; however, in clinical practice, collection of samples in the fasting state may be necessary to minimize the unpredictable effects of feeding.

TL;DR: Herein, I clarify exactly what such a belief implies, trace its origins, define the circumstances in which it is true, and specify the necessary qualifications, which are invariably omitted.

TL;DR: Histomorphometric analyses of iliac crest bone samples revealed findings similar to OI type I, with decreased cortical width and trabecular number, increased bone turnover, and preservation of the birefringent pattern of lamellar bone.

TL;DR: In this paper, Bone resorption was reduced by intake of food, glucose, fat, and protein and counteracted by fasting, and this seems to have been be independent of age and gender.

TL;DR: The effects of 3 years of risedronate treatment on bone histology and histomorphometry reflect the antiresorptive mechanism of action, and are consistent with the antifracture efficacy and favorable bone safety profile demonstrated in large clinical trials.

TL;DR: The data suggest that bone mechanosensitivity has a significant genetic component and could lead to therapies that enhance bone mass and reduce fracture susceptibility, and identify the genes that exert their influence on mechanos sensitivity.

TL;DR: The synthesis of complex inorganic forms, which mimic natural structures, offers exciting avenues for the chemical construction of macrostructures and a new generation of biologically and structurally related bone analogs for tissue engineering.

TL;DR: The measurement of BMD measured by quantitative computed tomography is considered to be helpful for the estimation of bone strength as well as for the prediction of intracortical porosity and parameters related to porous structures of cortical bone.

TL;DR: In assessing the evidence available, a working party derived from members of the Bone and Tooth Society and the National Association for the Relief of Paget’s Disease has adopted the guidelines prepared by the U.S. Agency for Health Care Policy and Research.

TL;DR: The fracture probabilities according to age, gender, and relative risk are reported, and the effects of changes in the gradient of risk for osteoporotic fractures on the sensitivity and specificity of assessments are investigated, modeled on the population of Sweden.