R
Romain Guinamard
Researcher at University of Caen Lower Normandy
Publications - 48
Citations - 2196
Romain Guinamard is an academic researcher from University of Caen Lower Normandy. The author has contributed to research in topics: Patch clamp & Internal medicine. The author has an hindex of 23, co-authored 41 publications receiving 1918 citations. Previous affiliations of Romain Guinamard include University of Poitiers & Centre national de la recherche scientifique.
Papers
More filters
Journal ArticleDOI
Gain-of-Function Mutations in TRPM4 Cause Autosomal Dominant Isolated Cardiac Conduction Disease
Hui Liu,Loubna El Zein,Martin Kruse,Romain Guinamard,Alf Beckmann,Andre Bozio,Gueven Kurtbay,André Mégarbané,Iris Ohmert,Gerard Blaysat,Elisabeth Villain,Olaf Pongs,Patrice Bouvagnet +12 more
TL;DR: The TRPM4 gene is a causative gene in isolated cardiac conduction disease with mutations resulting in a gain of function andTRPM4 channel being highly expressed in cardiac Purkinje fibers.
Journal ArticleDOI
The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells.
Gaetan Barbet,Marie Demion,Marie Demion,Ivan C. Moura,Ivan C. Moura,Nicolas Serafini,Nicolas Serafini,Thibaut Léger,Thibaut Léger,François Vrtovsnik,François Vrtovsnik,Renato C. Monteiro,Renato C. Monteiro,Romain Guinamard,Jean-Pierre Kinet,Pierre Launay,Pierre Launay +16 more
TL;DR: The results establish TRPM4-regulated Ca2+ homeostasis as crucial for DC mobility but not maturation and emphasize that DCmaturation and migration are independently regulated.
Journal ArticleDOI
Functional characterization of a Ca2+‐activated non‐selective cation channel in human atrial cardiomyocytes
Romain Guinamard,Aurélien Chatelier,Marie Demion,Daniel Potreau,Sylvie Patri,Mohammad Rahmati,Patrick Bois +6 more
TL;DR: The NSCCa channel is a serious candidate to support the delayed after‐depolarizations observed in [Ca2+] overload and thus may be implicated in the genesis of arrhythmias.
Journal ArticleDOI
TRPM4, a Ca2+-activated nonselective cation channel in mouse sino-atrial node cells
TL;DR: TRPM4 is functionally expressed in SAN cells and may be a key player in the generation and/or perturbation of heart rhythm, as a new property in cardiac cells.
Journal ArticleDOI
9-Phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels
Teddy Grand,Marie Demion,Marie Demion,Caroline Norez,Yvette Mettey,Pierre Launay,Frédéric Becq,Patrick Bois,Romain Guinamard,Romain Guinamard +9 more
TL;DR: This work investigated the effect of hydroxytricyclic compounds shown to modulate ABC transporters, on TRPM4 and TRPM5, a calcium‐activated non‐selective cation channels with almost identical characteristics that are inhibited by glibenclamide.