R
Romina P. Carnevale
Researcher at Instituto de Biología y Medicina Experimental
Publications - 6
Citations - 508
Romina P. Carnevale is an academic researcher from Instituto de Biología y Medicina Experimental. The author has contributed to research in topics: Mammary tumor & Signal transduction. The author has an hindex of 6, co-authored 6 publications receiving 479 citations.
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Journal ArticleDOI
TNF alpha acting on TNFR1 promotes breast cancer growth via p42/P44 MAPK, JNK, Akt and NF-kappa B-dependent pathways.
Martín A. Rivas,Romina P. Carnevale,Cecilia J. Proietti,Cinthia Rosemblit,Wendy Béguelin,Mariana Salatino,Eduardo H. Charreau,Isabel Frahm,Sandra Sapia,Peter Brouckaert,Patricia V. Elizalde,Roxana Schillaci +11 more
TL;DR: Evidence is revealed for TNFα as a breast tumor promoter, and novel data for a future therapeutic approach using TNF α antagonists and NF-κB pharmacological inhibitors in established breast cancer treatment is provided.
Journal ArticleDOI
Progestins Induce Transcriptional Activation of Signal Transducer and Activator of Transcription 3 (Stat3) via a Jak- and Src-Dependent Mechanism in Breast Cancer Cells
Cecilia J. Proietti,Mariana Salatino,Cinthia Rosemblit,Romina P. Carnevale,Adali Pecci,Alberto R. Kornblihtt,Alfredo A. Molinolo,Isabel Frahm,Eduardo H. Charreau,Roxana Schillaci,Patricia V. Elizalde +10 more
TL;DR: The results have for the first time demonstrated that progestins are able to induce Stat3 transcriptional activation, which is in turn an obligatory requirement for progestin stimulation of both in vitro and in vivo breast cancer growth.
Journal ArticleDOI
Progestin Effects on Breast Cancer Cell Proliferation, Proteases Activation, and in Vivo Development of Metastatic Phenotype All Depend on Progesterone Receptor Capacity to Activate Cytoplasmic Signaling Pathways
Romina P. Carnevale,Cecilia J. Proietti,Mariana Salatino,Alejandro J. Urtreger,Guillermo Peluffo,Dean P. Edwards,Viroj Boonyaratanakornkit,Eduardo H. Charreau,Elisa Bal de Kier Joffé,Roxana Schillaci,Patricia V. Elizalde +10 more
TL;DR: It is shown for the first time that progestins favor development of breast tumor metastasis via PR function as activator of signaling pathways, and mechanistic support to the design of a novel therapeutic intervention in PR-positive breast tumors involving blockage of PR capacity to activate cytoplasmic signaling.
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Inhibition of in vivo breast cancer growth by antisense oligodeoxynucleotides to type I insulin-like growth factor receptor mRNA involves inactivation of ErbBs, PI-3K/Akt and p42/p44 MAPK signaling pathways but not modulation of progesterone receptor activity.
Mariana Salatino,Roxana Schillaci,Cecilia J. Proietti,Romina P. Carnevale,Isabel Frahm,Alfredo A. Molinolo,Adolfo M. Iribarren,Eduardo H. Charreau,Patricia V. Elizalde +8 more
TL;DR: It is demonstrated for the first time that breast cancer growth can be inhibited by direct in vivo administration of IGF-IR AS[S]ODNs.
Journal ArticleDOI
Progestin-induced caveolin-1 expression mediates breast cancer cell proliferation
Mariana Salatino,Wendy Béguelin,María Giselle Peters,Romina P. Carnevale,Cecilia J. Proietti,Mario D. Galigniana,Cleber Giovane Vedoy,Roxana Schillaci,Eduardo H. Charreau,Mari Cleide Sogayar,Patricia V. Elizalde +10 more
TL;DR: It is demonstrated for the first time that caveolin-1 expression is upregulated by progestin in breast cancer and is a downstream effector of MPA that is partially responsible for the stimulation of growth of breast cancer cells.