R
Romy B. Christmann
Researcher at Boston University
Publications - 31
Citations - 2042
Romy B. Christmann is an academic researcher from Boston University. The author has contributed to research in topics: Interstitial lung disease & Fibrosis. The author has an hindex of 20, co-authored 31 publications receiving 1686 citations. Previous affiliations of Romy B. Christmann include University of São Paulo & Boston University Medical Campus.
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Journal ArticleDOI
Proteome-wide Analysis and CXCL4 as a Biomarker in Systemic Sclerosis
L. van Bon,L. van Bon,Alsya J. Affandi,Alsya J. Affandi,J. Broen,J. Broen,Romy B. Christmann,Renoud J. Marijnissen,Lukasz Stawski,Giuseppina Farina,Giuseppina Stifano,Allison L. Mathes,Marta Cossu,Michael York,Cindy Collins,Mark H. Wenink,R. Huijbens,Roger Hesselstrand,Tore Saxne,Michael DiMarzio,Dirk M. Wuttge,Sandeep K. Agarwal,John D. Reveille,Shervin Assassi,Maureen D. Mayes,Yanhui Deng,Joost P.H. Drenth,J. de Graaf,M. den Heijer,Cornelis Kallenberg,Marc Bijl,A. Loof,W.B. van den Berg,Leo A. B. Joosten,Vanessa Smith,F De Keyser,Raffaella Scorza,Claudio Lunardi,P.L.C.M. van Riel,Madelon C. Vonk,W.L. van Heerde,Stephan Meller,Bernhard Homey,Lorenzo Beretta,Mark Roest,Maria Trojanowska,Robert Lafyatis,Timothy R D J Radstake,Timothy R D J Radstake +48 more
TL;DR: Levels of CXCL4 were elevated in patients with systemic sclerosis and correlated with the presence and progression of complications, such as lung fibrosis and pulmonary arterial hypertension.
Journal ArticleDOI
Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients
Lisa M. Rice,Cristina Padilla,Sarah R. McLaughlin,Allison L. Mathes,Jessica Ziemek,Salma Goummih,Sashidhar Nakerakanti,Michael York,Giuseppina Farina,Michael L. Whitfield,Robert Spiera,Romy B. Christmann,Jessica K. Gordon,Janice Weinberg,Robert W. Simms,Robert Lafyatis +15 more
TL;DR: The rapid inhibition of TGF-β-regulated gene expression in response to fresolimumab strongly implicates TGF -β in the pathogenesis of fibrosis in SSc.
Journal ArticleDOI
Association of Interferon‐ and Transforming Growth Factor β–Regulated Genes and Macrophage Activation With Systemic Sclerosis–Related Progressive Lung Fibrosis
Romy B. Christmann,Romy B. Christmann,Percival D. Sampaio-Barros,Giuseppina Stifano,Claudia T. L. Borges,Carlos Roberto Ribeiro de Carvalho,Ronaldo Adib Kairalla,Edwin Roger Parra,Avrum Spira,Robert W. Simms,Vera L. Capellozzi,Robert Lafyatis +11 more
TL;DR: The gene expression of lung tissue in a prospective cohort of patients with SSc‐related ILD is analyzed and compared with that in control lungs and with 2 prospective clinical parameters in order to understand the molecular pathways implicated in progressive lung disease.
Journal ArticleDOI
Gastroesophageal reflux incites interstitial lung disease in systemic sclerosis: clinical, radiologic, histopathologic, and treatment evidence.
TL;DR: The association of GER with SSc-ILD is strongly supported by several studies, and an aggressive treatment for reflux is recommended in all SSc patients with ILD; however, future studies need to be performed to prove a long-term benefit.
Journal ArticleDOI
Interferon and alternative activation of monocyte/macrophages in systemic sclerosis–associated pulmonary arterial hypertension
Romy B. Christmann,Everett Hayes,Sarah A. Pendergrass,Sarah A. Pendergrass,Cristina Padilla,Giuseppina Farina,Alsya J. Affandi,Michael L. Whitfield,Harrison W. Farber,Robert Lafyatis +9 more
TL;DR: MRC1, a marker for the effect of IL-13 on alternative monocyte/macrophage activation, is associated with this severe complication and is related to mortality.