D
Dirk M. Wuttge
Researcher at Lund University
Publications - 64
Citations - 2018
Dirk M. Wuttge is an academic researcher from Lund University. The author has contributed to research in topics: Interstitial lung disease & Pulmonary fibrosis. The author has an hindex of 23, co-authored 62 publications receiving 1786 citations. Previous affiliations of Dirk M. Wuttge include Karolinska Institutet.
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Journal ArticleDOI
Proteome-wide Analysis and CXCL4 as a Biomarker in Systemic Sclerosis
L. van Bon,L. van Bon,Alsya J. Affandi,Alsya J. Affandi,J. Broen,J. Broen,Romy B. Christmann,Renoud J. Marijnissen,Lukasz Stawski,Giuseppina Farina,Giuseppina Stifano,Allison L. Mathes,Marta Cossu,Michael York,Cindy Collins,Mark H. Wenink,R. Huijbens,Roger Hesselstrand,Tore Saxne,Michael DiMarzio,Dirk M. Wuttge,Sandeep K. Agarwal,John D. Reveille,Shervin Assassi,Maureen D. Mayes,Yanhui Deng,Joost P.H. Drenth,J. de Graaf,M. den Heijer,Cornelis Kallenberg,Marc Bijl,A. Loof,W.B. van den Berg,Leo A. B. Joosten,Vanessa Smith,F De Keyser,Raffaella Scorza,Claudio Lunardi,P.L.C.M. van Riel,Madelon C. Vonk,W.L. van Heerde,Stephan Meller,Bernhard Homey,Lorenzo Beretta,Mark Roest,Maria Trojanowska,Robert Lafyatis,Timothy R D J Radstake,Timothy R D J Radstake +48 more
TL;DR: Levels of CXCL4 were elevated in patients with systemic sclerosis and correlated with the presence and progression of complications, such as lung fibrosis and pulmonary arterial hypertension.
Journal ArticleDOI
CXCL16/SR-PSOX is an interferon-gamma-regulated chemokine and scavenger receptor expressed in atherosclerotic lesions.
Dirk M. Wuttge,Xinghua Zhou,Yuri Sheikine,Dick Wågsäter,Veronika Stemme,Ulf Hedin,Sten Stemme,Göran K. Hansson,Allan Sirsjö +8 more
TL;DR: A novel role of IFN-&ggr; in foam cell formation through upregulation of CXCL16/SR-PSOX is demonstrated, which could serve as a molecular link between lipid metabolism and immune activity in the atherosclerotic lesion.
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The Pronounced Th17 Profile in Systemic Sclerosis (SSc) Together with Intracellular Expression of TGFβ and IFNγ Distinguishes SSc Phenotypes
Timothy R D J Radstake,Timothy R D J Radstake,Lenny van Bon,Lenny van Bon,J. Broen,J. Broen,Anila Hussiani,Roger Hesselstrand,Dirk M. Wuttge,Yanhui Deng,Robbert Simms,Erik Lubberts,Robert Lafyatis +12 more
TL;DR: The combination of IL-17, IFNγ and TGFβ levels in CD45Ro and CD45Ra cells from SSc patients is useful to distinguish between lSSc, ldSSc or edSSc and may provide a useful tool to intervene in the progression of SSc.
Journal ArticleDOI
Differential Expression of Cysteine and Aspartic Proteases during Progression of Atherosclerosis in Apolipoprotein E-Deficient Mice
Sofia Jormsjö,Dirk M. Wuttge,Allan Sirsjö,Carl Whatling,Anders Hamsten,Sten Stemme,Per Eriksson +6 more
TL;DR: Increased expression of several cathepsins in atherosclerotic lesions suggests that these proteases may participate in the remodeling of extracellular matrix associated with the atherosclerosis process.
Journal ArticleDOI
Metabolic Profiling of Systemic Lupus Erythematosus and Comparison with Primary Sjögren’s Syndrome and Systemic Sclerosis
Anders A. Bengtsson,Johan Trygg,Dirk M. Wuttge,Gunnar Sturfelt,Elke Theander,Magdalena Donten,Thomas Moritz,Carl Johan Sennbro,Frida Torell,Christian Lood,Izabella Surowiec,Stefan Rännar,Torbjörn Lundstedt +12 more
TL;DR: It is shown that metabolomics can be used as a tool for improved diagnosis of SLE compared to other similar autoimmune diseases and the most discriminatory metabolite observed was tryptophan, with decreased levels in SLE patients compared to control groups.