R
Ronit Sagi-Eisenberg
Researcher at Tel Aviv University
Publications - 69
Citations - 6937
Ronit Sagi-Eisenberg is an academic researcher from Tel Aviv University. The author has contributed to research in topics: Exocytosis & Mast cell. The author has an hindex of 23, co-authored 65 publications receiving 6247 citations.
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Journal ArticleDOI
Neuronal Calcium Sensor-1 and Phosphatidylinositol 4-Kinase β Stimulate Extracellular Signal-regulated Kinase 1/2 Signaling by Accelerating Recycling through the Endocytic Recycling Compartment
Yaara Kapp-Barnea,Lihi Ninio-Many,Koret Hirschberg,Mitsunori Fukuda,Andreas Jeromin,Ronit Sagi-Eisenberg +5 more
TL;DR: A novel role for NCS-1 and PI4Kbeta in regulating ERK1/2 signaling and inflammatory reactions in mast cells is demonstrated and the ERC is identified as a crucial determinant in controlling ERK 1/ 2 signaling.
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Activation of mast cells by trimeric G protein Gi3; coupling to the A3 adenosine receptor directly and upon T cell contact.
TL;DR: The physiological G-protein coupled receptor that couples to Gi3 is unveiled and the important role played by this G- protein in inflammatory conditions that involve adenosine-activated mast cells is established.
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Role of Mast Cell-Derived Adenosine in Cancer.
TL;DR: The evidence on the role of adenosine signaling in cancer, in MC mediated inflammation and in the MC-cancer crosstalk is summarized.
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Molecular impacts of rapamycin-based drug combinations: combining rapamycin with gemcitabine or imatinib mesylate (Gleevec) in a human leiomyosarcoma model.
TL;DR: Combining gemcitabine and rapamycin produces a major effect on the cell cycle, elevates the DeltaPhim even further and maintains the molecular impacts exerted by each single drug.
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Rab5 is critical for SNAP23 regulated granule-granule fusion during compound exocytosis
Ofir Klein,Amit Roded,Neta Zur,Nurit P. Azouz,Nurit P. Azouz,Olga Pasternak,Koret Hirschberg,Ilan Hammel,Paul A. Roche,Ayaka Yatsu,Mitsunori Fukuda,Stephen J. Galli,Ronit Sagi-Eisenberg +12 more
TL;DR: The findings identify Rab5 as a heretofore-unrecognized regulator of compound exocytosis that is essential for SNAP23-mediated granule-granule fusion, and implicate phosphorylation cycles in controlling SNAP23 SNARE function in homotypic SG fusion.