Ronit Sagi-Eisenberg

TL;DR: It is shown that compound 48/80 (c48/80), a synthetic member of the class of basic secretagogues, stimulates protein tyrosine phosphorylation of a number of as yet unidentified cellular substrates, suggesting that basic secretagogue induce protein tyrose phosphorylated as part of their parallel multiple signaling pathways which are presumably mediated by more than one G‐protein.

TL;DR: The association between the reprogramming of glucose metabolism in the TME and oncogenic signaling and its reflection in the non-canonical functions of metabolic enzymes is discussed and special emphasis is given in this regard to lysophosphatidic acid (LPA) and adenosine, two powerful metabolites, the concentrations of which rise in theTME due to altered metabolism of the tumor and its surrounding cells.

TL;DR: Exposure of MCs to EVs derived from pancreatic cancer cells or non–small cell lung carcinoma results in MC activation, evident by the increased phosphorylation of the ERK1/2 MAP kinases, and activation by EVs upregulates expression of angiogenic and tissue remodeling genes.

TL;DR: The human mast cell A3R is identified as regulator of tissue remodeling gene expression in human mast cells and a heretofore-unrecognized mode of feedback regulation that is exerted by this receptor is demonstrated.

TL;DR: The possible reasons for the mast cell to utilize compound exocytosis during anaphylaxis, the conflicting evidence in different mast cell models, and the open questions in the field which remain to be answered are discussed.